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The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases
Inflammatory response represents one of the first immune processes following injury. It is characterized by the production of various molecules that initiate the recruitment of immune cells to theExpand
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ER stress induces NLRP3 inflammasome activation and hepatocyte death
The incidence of chronic liver disease is constantly increasing, owing to the obesity epidemic. However, the causes and mechanisms of inflammation-mediated liver damage remain poorly understood.Expand
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Impaired processing of brain proneurotensin and promelanin-concentrating hormone in obese fat/fat mice.
Mice homozygous for the fat mutation exhibit marked hyperpro-insulinemia and develop late onset obesity. The fat mutation was recently mapped to the gene encoding carboxypeptidase E (CpE), aExpand
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Variations in circulating inflammatory factors are related to changes in calorie and carbohydrate intakes early in the course of surgery-induced weight reduction.
BACKGROUND Obesity is considered a low-grade inflammatory state that improves with weight loss. In addition to acute-phase proteins, other cytokines might contribute to systemic inflammation. Expand
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Stromal cell‐derived factor‐1α modulation of the excitability of rat substantia nigra dopaminergic neurones: presynaptic mechanisms
In rat substantia nigra (SN), Chemokine (CXC motif) receptor 4 (CXCR4) for the chemokine stromal cell‐derived factor (SDF)‐1α is expressed on dopaminergic (DA) neurones, but also on non‐DA cells,Expand
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The chemokine stromal cell‐derived factor‐1/CXCL12 activates the nigrostriatal dopamine system
We recently demonstrated that dopaminergic (DA) neurons of the rat substantia nigra constitutively expressed CXCR4, receptor for the chemokine stromal cell‐derived factor‐1 (SDF‐1)/CXCL12 (SDF‐1). ToExpand
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The complex contribution of chemokines to neuroinflammation: switching from beneficial to detrimental effects
Inflammation is an innate mechanism that defends organisms against harmful stimuli. Inflammation leads to the production and secretion of proinflammatory mediators that activate and recruit immuneExpand
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Dietary supplementation of alpha-linolenic acid in an enriched rapeseed oil diet protects from stroke.
Populations of Western countries are severely deficient in omega-3 intake, both in the form of alpha-linolenic acid (ALA) and the Long Chain derivatives (LC-n-3), Eicosa-Pentaenoic-Acid andExpand
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Complex effects of stromal cell‐derived factor‐1α on melanin‐concentrating hormone neuron excitability
Stromal cell‐derived factor 1α (SDF‐1α), a chemoattractant for leucocytes and neurons, and its receptor, CXCR4 are expressed in subsets of neurons of specific brain areas. In rat lateral hypothalamicExpand
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The RGD Motif and the C-terminal Segment of Proprotein Convertase 1 Are Critical for Its Cellular Trafficking but Not for Its Intracellular Binding to Integrin α5β1 *
Cellular trafficking of subtilisin/kexin-like precursor convertases (PCs) may be regulated by a number of motifs, some of which are present within the P-domain and in the C-terminal sequence. Six ofExpand
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