Serine Proteases

Known as: Serine proteinases, Proteinase, Serine, Serine Proteases [Chemical/Ingredient] 
Proteases that have a serine residue in the active center of the enzyme. These enzymes catalyze the hydrolysis of covalent peptidic bonds by serine… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Neutrophils, or polymorphonuclear leukocytes, comprise a crucial component of innate immunity, controlling bacterial and fungal… (More)
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Highly Cited
2008
Highly Cited
2008
Hepcidin, a liver-derived protein that restricts enteric iron absorption, is the key regulator of body iron content. Several… (More)
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Highly Cited
2008
Highly Cited
2008
The liver peptide hepcidin regulates body iron, is upregulated in iron overload and inflammation, and is downregulated in iron… (More)
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Highly Cited
2005
Highly Cited
2005
There is a rapid global rise in obesity, and the link between obesity and diabetes remains somewhat obscure. We identified an… (More)
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Highly Cited
2003
Highly Cited
2003
Persistent infections with hepatitis C virus (HCV) are likely to depend on viral inhibition of host defenses. We show that the… (More)
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Highly Cited
2002
Highly Cited
2002
To identify human proteins that bind to the Smac and caspase-9 binding pocket on the baculoviral inhibitor of apoptosis protein… (More)
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Highly Cited
2002
Highly Cited
2002
The inhibitor-of-apoptosis proteins (IAPs) play a critical role in the regulation of apoptosis by binding and inhibiting caspases… (More)
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Highly Cited
2001
Highly Cited
2001
The polytopic membrane protein Rhomboid-1 promotes the cleavage of the membrane-anchored TGFalpha-like growth factor Spitz… (More)
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Highly Cited
2000
Highly Cited
2000
Chronic pancreatitis (CP) is a continuing or relapsing inflammatory disease of the pancreas. In approximately one-third of all… (More)
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Highly Cited
2000
Highly Cited
2000
We describe here eleven different mutations in SPINK5, encoding the serine protease inhibitor LEKTI, in 13 families with… (More)
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