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Acne rosacea is an inflammatory skin disease that affects 3% of the US population over 30 years of age and is characterized by… Expand Persistent infections with hepatitis C virus (HCV) are likely to depend on viral inhibition of host defenses. We show that the… Expand To identify human proteins that bind to the Smac and caspase-9 binding pocket on the baculoviral inhibitor of apoptosis protein… Expand X chromosome-linked inhibitor of apoptosis (XIAP) is an endogenous inhibitor of caspase-3, -7, and -9. Smac/DIABLO, an inhibitor… Expand Chronic pancreatitis (CP) is a continuing or relapsing inflammatory disease of the pancreas. In approximately one-third of all… Expand We describe here eleven different mutations in SPINK5, encoding the serine protease inhibitor LEKTI, in 13 families with… Expand The complement system comprises a complex array of enzymes and non-enzymatic proteins that is essential for the operation of the… Expand Structure‐based mutational analysis of serine protease specificity has produced a large database of information useful in… Expand TRUE Upases attack triacylglycerols and act at an oil–water interface; they constitute a ubiquitous group of enzymes catalysing a… Expand A 33-kD glycoprotein, known as the "prostate-specific antigen," was purified to homogeneity from human seminal plasma. The… Expand