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Proenkephalin-A, human

Known as: Preproenkephalin, Proenkephalin-A, Proenkephalin A 
Proenkephalin-A (267 aa, ~31 kDa) is encoded by the human PENK gene. This protein is involved in opioid receptor signaling.
National Institutes of Health

Related topics

Related topics

8 relations
NeuronsNociceptionPENK geneReceptor Signaling

Broader (2)

preproenkephalin Aproenkephalin A

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2001
2001
Prenatal nicotine affects catecholamine gene expression in newborn rat carotid body and petrosal ganglion.
Nicotine exposure modifies the expression of catecholamine and opioid neurotransmitter systems involved in attenuation of hypoxic… 
Highly Cited
1997
Highly Cited
1997
Enkephalinergic and dynorphinergic neurons in the spinal cord and dorsal root ganglia of the polyarthritic rat — in vivo release and cDNA hybridization studies
Highly Cited
1995
Highly Cited
1995
Chronicl-DOPA treatment differentially regulates gene expression of glutamate decarboxylase, preproenkephalin and preprotachykinin in the striatum of 6-hydroxydopamine-lesioned rat
Highly Cited
1989
Highly Cited
1989
Cellular localisation of enkephalin gene expression in MPTP-treated cynomolgus monkeys.
Highly Cited
1988
Highly Cited
1988
A common trans-acting factor is involved in transcriptional regulation of neurotransmitter genes by cyclic AMP
Activation of neurotransmitter receptors can regulate transcription in postsynaptic cells through the actions of second… 
Highly Cited
1987
Highly Cited
1987
Involvement of ion channels in the induction of proenkephalin A gene expression by nicotine and cAMP in bovine chromaffin cells.
Highly Cited
1986
Highly Cited
1986
Glucocorticoids and cyclic AMP synergistically regulate the abundance of preproenkephalin messenger RNA in neuroblastoma-glioma hybrid cells.
Review
1985
Review
1985
Isolation and structure of a novel C-terminally amidated opioid peptide, amidorphin, from bovine adrenal medulla
Biologically active peptide hormones and neurotransmitters have been shown to be enzymatically liberated from larger, inactive… 
Highly Cited
1984
Highly Cited
1984
Polymorphism and absence of Leu-enkephalin sequences in proenkephalin genes in Xenopus laevis
The structures of the genes coding for the opioid peptide precursors proopiomelanocortin, proenkephalin (proenkephalin A) and… 
Highly Cited
1984
Highly Cited
1984
Effect of intranigral injections of dynorphin, dynorphin fragments and alpha-neoendorphin on rotational behaviour in the rat.
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