Corticocortical inhibition in human motor cortex.
In ten normal volunteers, a transcranial magnetic or electric stimulus that was subthreshold for evoking an EMG response in relaxed muscles was used to condition responses evoked by a later, suprathreshold magnetic orElectric test shock to suggest that the suppression was produced by an action on cortical, rather than spinal excitability.
Interhemispheric inhibition of the human motor cortex.
- A. Ferbert, A. Priori, J. Rothwell, B. Day, J. Colebatch, C. Marsden
- Psychology, BiologyJournal of Physiology
- 1 July 1992
In contrast to the inhibition of test responses evoked by magnetic test stimuli, test responsesevoked in active FDI by a small anodal electric shock were not significantly inhibited by a contralateral magnetic conditioning stimulus, and H reflexes in relaxed forearm flexor muscles were unaffected by conditioning stimuli to the ipsilateral hemisphere.
Electric and magnetic stimulation of human motor cortex: surface EMG and single motor unit responses.
1. The effects of different forms of brain stimulation on the discharge pattern of single motor units were examined using the post‐stimulus time histogram (PSTH) technique and by recording the…
Postural electromyographic responses in the arm and leg following galvanic vestibular stimulation in man
- T. Britton, B. Day, P. Brown, J. Rothwell, P. Thompson, C. Marsden
- BiologyExperimental Brain Research
The difference in latency between the onset of the early component of the response in arm and leg muscles suggests that this part of the responded uses a descending pathway which conducts impulses down the spinal cord with a velocity comparable with that of the fast conducting component ofThe corticospinal tract.
Validity and reliability of a rating scale for the primary torsion dystonias
- R. E. Burke, S. Fahn, C. Marsden, S. Bressman, C. Moskowitz, Joseph Friedman
- Medicine, PsychologyNeurology
- 1 January 1985
The Movement Scale was a valid and reliable indicator of the severity of primary torsion dystonia and was found to be compatible with scores on the Disability Scale.
Fronto-striatal cognitive deficits at different stages of Parkinson's disease.
Groups of patients with idiopathic Parkinson's disease, either medicated or unmedicated, were compared with matched groups of normal controls on a computerized battery previously shown to be…
Self-initiated versus externally triggered movements. I. An investigation using measurement of regional cerebral blood flow with PET and movement-related potentials in normal and Parkinson's disease…
- M. Jahanshahi, I. Jenkins, R. Brown, C. Marsden, R. Passingham, D. Brooks
- Psychology, BiologyBrain : a journal of neurology
- 1 August 1995
During the self-initiated movements, the lower amplitude of the early BP in patients with Parkinson's disease as well as the underactivation of the supplementary motor area relative to normals support the premises that (i) the supplementaryMotor area contributes to the earlyBP, and (ii) the deficit in self- initiated movement is due to supplementary Motor area underactivation.
'Frontal' cognitive function in patients with Parkinson's disease 'on' and 'off' levodopa.
The results suggest that different areas of prefrontal cortex are involved in the tasks employed, and that functional levels of dopamine in separate areas of cortex and caudate may differ crucially in Parkinson's disease.
Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia.
An increase in total iron content appears to be a response to neurodegeneration in affected basal ganglia regions in a number of movement disorders, suggesting an alteration of iron handling in the substantia nigra in PD.