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Corticocortical inhibition in human motor cortex.
1. In ten normal volunteers, a transcranial magnetic or electric stimulus that was subthreshold for evoking an EMG response in relaxed muscles was used to condition responses evoked by a later,Expand
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Interhemispheric inhibition of the human motor cortex.
1. Using two magnetic stimulators, we investigated the effect of a conditioning magnetic stimulus over the motor cortex of one hemisphere on the size of EMG responses evoked in the first dorsalExpand
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Validity and reliability of a rating scale for the primary torsion dystonias
For quantitative assessment of the primary torsion dystonias, a rating scale is proposed that has two sections—a Movement Scale, based on examination, and a Disability Scale, based on the patient'sExpand
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Electric and magnetic stimulation of human motor cortex: surface EMG and single motor unit responses.
1. The effects of different forms of brain stimulation on the discharge pattern of single motor units were examined using the post‐stimulus time histogram (PSTH) technique and by recording theExpand
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Fronto-striatal cognitive deficits at different stages of Parkinson's disease.
Groups of patients with idiopathic Parkinson's disease, either medicated or unmedicated, were compared with matched groups of normal controls on a computerized battery previously shown to beExpand
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New observations on the normal auditory startle reflex in man.
The latency and pattern of muscle recruitment in the startle response elicited by unexpected auditory stimulation was determined in 12 healthy subjects. Reflex EMG activity was recorded first inExpand
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Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease
Abstract: Polyunsaturated fatty acid (PUFA) levels (an index of the amount of substrate available for lipid peroxidation) were measured in several brain regions from patients who died withExpand
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'Frontal' cognitive function in patients with Parkinson's disease 'on' and 'off' levodopa.
A wide range of cognitive impairments can be observed in patients with Parkinson's disease. A close parallel exists between these deficits and those found following damage to prefrontal cortex.Expand
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Oxidative DNA Damage in the Parkinsonian Brain: An Apparent Selective Increase in 8‐Hydroxyguanine Levels in Substantia Nigra
Abstract: Oxidative damage has been implicated in the pathology of Parkinson's disease (PD), e.g., rises in the level of the DNA damage product, 8‐hydroxy‐2′‐deoxyguanosine, have been reported.Expand
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Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia
Reduced glutathione (GSH) and oxidized glutathione (GSSG) levels were measured in various brain areas (substantia nigra, putamen, caudate nucleus, globus pallidus, and cerebral cortex) from patientsExpand
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