• Publications
  • Influence
Animal models of neuropsychiatric disorders
TLDR
The current state of animal models of mental illness, with a focus on schizophrenia, depression and bipolar disorder, is reviewed and it is argued for areas of focus that might increase the likelihood of creating more useful models, at least for some disorders.
Neural mechanisms of addiction: the role of reward-related learning and memory.
TLDR
Progress in identifying candidate mechanisms of addiction is reviewed, including molecular and cellular mechanisms that underlie long-term associative memories in several forebrain circuits (involving the ventral and dorsal striatum and prefrontal cortex) that receive input from midbrain dopamine neurons.
Grand challenges in global mental health
A consortium of researchers, advocates and clinicians announces here research priorities for improving the lives of people with mental illness around the world, and calls for urgent action and
The Hierarchical Taxonomy of Psychopathology (HiTOP): A Dimensional Alternative to Traditional Nosologies
TLDR
The HiTOP promises to improve research and clinical practice by addressing the aforementioned shortcomings of traditional nosologies and provides an effective way to summarize and convey information on risk factors, etiology, pathophysiology, phenomenology, illness course, and treatment response.
Addiction and the brain: The neurobiology of compulsion and its persistence
TLDR
Evidence is reviewed for the possibility that compulsion and its persistence are based on a pathological usurpation of molecular mechanisms that are normally involved in memory, which is often initiated by exposure to drug-related cues.
The diagnosis of mental disorders: the problem of reification.
  • S. Hyman
  • Psychology, Medicine
    Annual review of clinical psychology
  • 24 March 2010
TLDR
Based on accreting problems with the current DSM-fourth edition (DSM-IV) classification, it is apparent that validity will not be achieved simply by refining criteria for existing disorders or by the addition of new disorders.
Computational roles for dopamine in behavioural control
TLDR
The application of such quantitative models has opened up new fields, ripe for attack by young synthesizers and theoreticians, to describe the biological algorithms at play in their brains when the authors form value judgements and make choices.
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