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The dorsal horn of the spinal cord is the location of the first synapse in pain pathways, and as such, offers a very powerful… Expand We describe a paradigm for nociception in Drosophila. In response to the touch of a probe heated above 38 degrees C, Drosophila… Expand The sensation of pain alerts us to real or impending injury and triggers appropriate protective responses. Unfortunately, pain… Expand The study of pain in awake animals raises ethical, philosophical, and technical problems. We review the ethical standards for… Expand The capsaicin (vanilloid) receptor VR1 is a cation channel expressed by primary sensory neurons of the "pain" pathway… Expand It is generally acknowledged that humans display highly variable sensitivity to pain, including variable responses to identical… Expand The peptide neurotransmitter substance P modulates sensitivity to pain by activating the neurokinin-1 (NK-1) receptor, which is… Expand &NA; The involvement of the basal ganglia in motor functions has been well studied. Recent neurophysiological, clinical and… Expand Nerve growth factor (NGF) is thought of as a target-derived factor responsible for the survival and maintaining the phenotype of… Expand &NA; A method to measure cutaneous hyperalgesia to thermal stimulation in unrestrained animals is described. The testing paradigm… Expand