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Inhibition of adipocyte differentiation by mechanical stretching through ERK-mediated downregulation of PPARγ2
TLDR
The results suggest that the inhibition of adipocyte differentiation in response to stretching is mainly attributable to the reduced expression of PPARγ2, which is mediated by activation of the ERK/MAPK system. Expand
20‐Hydroxyeicosatetraenoic acid potentiates stretch‐induced contraction of canine basilar artery via PKCα‐mediated inhibition of KCa channel
TLDR
Results suggest that 20‐HETE induced sensitization of the canine basilar artery to stretch was caused by PKCα‐mediated inhibition of KCa channel activity. Expand
Mechanical stretch augments PDGF receptor β expression and protein tyrosine phosphorylation in pulmonary artery tissue and smooth muscle cells
TLDR
Results suggest that stretch-induced overexpression of cell-surface PDGF-Rβ as well as augmentation of tyrosine phosphorylation of proteins including FAK in PASMC might be involved in the mechanotransduction of pulmonary artery. Expand
Interactive Role of Protein Kinase C-δ with Rho-Kinase in the Development of Cerebral Vasospasm in a Canine Two-Hemorrhage Model
TLDR
The development of cerebral vasospasm after SAH (on day 4) is caused by at least two mechanisms: one involves M LC20 phosphorylation mediated by the inhibition of MLC20 phosphatase by Rho-kinase, and the other CaDosphorylationmediated by the activation of PKC-δ by R HO, which results in the alleviation of the inhibition by CaD of myosin Mg2+-ATPase activity. Expand
Involvement of cyclooxygenase-2 in synergistic effect of cyclic stretching and eicosapentaenoic acid on adipocyte differentiation.
TLDR
It appears that the stretching and EPA exhibit a synergistic effect for the inhibition of adipocyte differentiation through stretch-induced COX-2. Expand
Evidence for Protein Kinase C-Mediated Activation of Rho- Kinase in a Porcine Model of Coronary Artery Spasm
TLDR
Results demonstrate that PKC and Rho-kinase coexist on the same intracellular signaling pathway, with PKC located upstream on Rho -kinase, and that among the PKC isoforms, only PKC&dgr; may be involved. Expand
Dual effect of nitric oxide on cytosolic Ca2+ concentration and insulin secretion in rat pancreatic beta-cells.
TLDR
The results suggest that NO facilitates glucose-induced [Ca(2+)](c) oscillations of beta-cells and insulin secretion at low concentrations, which effects are mediated by cGMP, whereas NO inhibits them in a cG MP-independent manner at high concentrations. Expand
Local regulation of skin blood flow during cooling involving presynaptic P2 purinoceptors in rats
TLDR
A novel mechanism for local cooling‐induced reduction of skin blood flow in vivo is suggested, which stimulates presynaptic P2 purinoceptors on sympathetic nerve terminals and facilitates the release of noradrenaline, thereby causing contractions of skinBlood vessels via the activation of α1‐and α2‐adrenoceptors. Expand
Potentiation by endothelin-1 of Ca2+ sensitivity of contractile elements depends on Ca2+ influx through L-type Ca2+ channels in the canine cerebral artery.
TLDR
It is suggested that ET-1 contracts the canine cerebral artery by increasing not only theCa2+ influx through L-type Ca2+ channels, but also Ca2- release from the intracellular storage sites, and also Ca 2+ sensitivity of contractile elements. Expand
Interactive role of tyrosine kinase, protein kinase C, and Rho/Rho kinase systems in the mechanotransduction of vascular smooth muscles.
TLDR
The study of the mechanotransduction in vascular tissue may aid in clarifying the mechanisms underlying vasospastic episodes and pathologic remodeling in cardiovascular diseases, and may potentially have therapeutic consequences. Expand
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