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High Affinity Nerve Growth Factor Receptor, human

Known as: Trk-A, Nerve Growth Factor Receptor Type 1, Tropomyosin-Related Kinase A 
High affinity nerve growth factor receptor (796 aa, ~87 kDa) is encoded by the human NTRK1 gene. This protein is involved in tyrosine phosphorylation… 
National Institutes of Health

Related topics

Related topics

29 relations
ApoptosisCell Differentiation processCell ProliferationEnzyme Gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Novel Neurotrophic Tyrosine Kinase Receptor Type 1 Gene Mutation Associated With Congenital Insensitivity to Pain With Anhidrosis
Congenital insensitivity to pain with anhidrosis (hereditary sensory and autonomic neuropathy type IV) is a rare autosomal… 
2008
2008
Novel missense, insertion and deletion mutations in the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1) associated with congenital insensitivity to pain with anhidrosis
2006
2006
Identification of differentially expressed genes in papillary thyroid carcinomas with and without rearrangements of the tyrosine kinase receptors RET and/or NTRK1.
Review
2005
Review
2005
Assays for membrane tyrosine kinase receptors: methods for high-throughput screening and utility for diagnostics
The development of novel antagonists or agonists of membrane tyrosine kinase receptors is a large focus of discovery research… 
Highly Cited
2004
Highly Cited
2004
Expression of Ligand-Activated KIT and Platelet-Derived Growth Factor Receptor β Tyrosine Kinase Receptors in Synovial Sarcoma
Purpose: The use of tyrosine kinase receptor inhibitors is increasingly becoming a valuable therapeutic alternative in tumors… 
2000
2000
HMG-CoA reductase inhibitor induces a transient activation of high affinity nerve growth factor receptor, Trk, and morphological differentiation with fatal outcome in PC12 cells
1999
1999
Mutation analysis reveals novel sequence variants in NTRK1 in sporadic human medullary thyroid carcinoma.
Tyrosine kinase NTRK1 is expressed in neural and nonneuronal tissues. Like RET, NTRK1 is often activated by rearrangements that… 
Highly Cited
1995
Highly Cited
1995
Interaction with TrkA Immobilizes gp75 in the High Affinity Nerve Growth Factor Receptor Complex (*)
It has been proposed that the high affinity nerve growth factor (NGF) receptor required for NGF response is a complex of two… 
1994
1994
Neurotrophin‐3 acquires NGF‐like activity after exchange to five NGF amino acid residues: Molecular analysis of the sites in NGF mediating the specific interaction with the NGF high affinity receptor
Despite the large sequence similarity around 55–60% among the known NGF‐related neurotrophins, the members display different… 
1994
1994
Characterization and growth-dependent regulation of the nerve growth factor receptor gp140trk in rat C6 glioma cells.
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