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The P2X7 purinergic receptor: from physiology to neurological disorders
TLDR
The P2X7 receptor may represent a critical communication link between the nervous and immune systems, while providing a target for therapeutic exploitation in neurological/psychiatric diseases and in the pathophysiology of depression.
Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide.
TLDR
It is reported that mast cells express both the gene and a functional CB2 receptor protein with negative regulatory effects on mast cell activation, and palmitoylethanolamide and its derivatives may provide antiinflammatory therapeutic strategies specifically targeted to mast cells.
Amyloid β‐peptide(1–42) and hydrogen peroxide‐induced toxicity are mediated by TRPM2 in rat primary striatal cultures
TLDR
It is demonstrated that activation of TRPM2, functionally expressed in primary cultures of rat striatum, contributes to Aβ‐ and oxidative stress‐induced striatal cell death.
TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP‐ribose) polymerase
TLDR
The data suggest that oxidative stress causes TRPM2 channel opening in both recombinant and endogenously expressing cell systems via activation of PARP enzymes.
The biology of neurotrophins, signalling pathways, and functional peptide mimetics of neurotrophins and their receptors.
  • S. Skaper
  • Biology
    CNS & neurological disorders drug targets
  • 31 January 2008
TLDR
In conclusion, exciting recent data describing G-protein-coupled receptor transactivation of Trk receptors and their downstream signalling pathways raise the possibility of using small molecules to elicit neuroprotective effects.
Selective small‐molecule inhibitors of glycogen synthase kinase‐3 activity protect primary neurones from death
TLDR
The data provide clear pharmacological and biochemical evidence that selective inhibition of the endogenous pool of GSK‐3 activity in primary neurones is sufficient to prevent death, implicating G SK‐3 as a physiologically relevant principal regulatory target of the PI’3‐kinase/PKB neuronal survival pathway.
The neurotrophin family of neurotrophic factors: an overview.
  • S. Skaper
  • Biology
    Methods in molecular biology
  • 2012
TLDR
Neurotrophin availability is required into adulthood, where they control synaptic function and plasticity and sustain neuronal cell survival, morphology, and differentiation.
TRPM2 Is Elevated in the tMCAO Stroke Model, Transcriptionally Regulated, and Functionally Expressed in C13 Microglia
TLDR
It is demonstrated that increased intracellular adenosine diphosphoribose or extracellular H2O2 induced an inward current, consistent with activation of TRPM2, which is present in the human C13 microglial cell line and is reduced by antisense treatment.
The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons.
TLDR
The results suggest that non-CB1 cannabinoid receptors control, upon agonist binding, the downstream consequences of an excitotoxic stimulus and activation of such receptors may serve to downmodulate deleterious cellular processes following pathological events or noxious stimuli in both the nervous and immune systems.
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