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Nicorandil as a hybrid between nitrates and potassium channel activators.
  • N. Taira
  • Medicine, Biology
    The American journal of cardiology
  • 20 June 1989
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Antiarrhythmic and bradycardic drugs inhibit currents of cloned K+ channels, KV1.2 and KV1.4.
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KCl-depolarization potentiates the Ca2+ sensitization by endothelin-1 in canine coronary artery.
TLDR
It is suggested that KCl-depolarization potentiates the Ca2+ sensitization by ET-1, which increases the force of contraction without any changes in intracellular calcium concentration in canine coronary artery.
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Differential sensitivity of Kv1.4, Kv1.2, and their tandem channel to acidic pH: involvement of a histidine residue in high sensitivity to acidic pH.
TLDR
The results suggest that the histidine residue at 508 in the S5-H5 linker plays a critical role in determining pH sensitivity and voltage dependence of pH effects of voltage-gated K+ channels, and the two parent channels, Kv 1.2 and Kv1.4, are involved in determining acidity sensitivity and apparent voltage dependence.
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Effects of new inotropic agents on cyclic nucleotide metabolism and calcium transients in canine ventricular muscle.
TLDR
The results indicate that the accumulation of cyclic AMP resulting from the inhibition of cyclIC AMP phosphodiesterase plays an important role in the action of new positive inotropic agents, milrinone, amrinone , MDL 17,043, MDL 19,205, OPC-8212, and sulmazole (less than or equal to 3 X 10(-4)M), on dog ventricular muscle.
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Differences in cardiovascular profile among calcium antagonists.
  • N. Taira
  • Medicine, Chemistry
    The American journal of cardiology
  • 30 January 1987
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PHARMACOLOGICAL PROFILE OF A NEW CORONARY VASODILATOR DRUG, 2‐NICOTINAMIDOETHYL NITRATE (SG‐75)
1. In anaesthetized, open‐chest dogs, 2‐nicotinamidoethyl nitrate (SG‐75) administered intravenously (0.3–1 mg/kg) or intraduodenally (3 mg/kg) produced decreases in systemic blood pressure, coronary…
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Similarity and Dissimilarity in the Mode and Mechanism of Action Between Nicorandil and Classical Nitrates: An Overview
  • N. Taira
  • Biology
    Journal of cardiovascular pharmacology
  • 1987
TLDR
The activity of nicorandil to increase the membrane potassium conductance resides in the nicotinamide moiety, however, this activity is greatly enhanced by the presence of the nitrate group at an appropriate distance from the Nicotinamide group.
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Is staurosporine a specific inhibitor of protein kinase C in intact porcine coronary arteries?
TLDR
The results suggest that staurosporine is a relatively specific inhibitor of protein kinase C in intact arteries at lower concentrations, while at higher concentrations it may have actions unrelated to its inhibitory effect of protein Kinase C, which include the inhibition of calcium influx into smooth muscle cells through the voltage-dependent Ca++ channel.
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Membrane current changes responsible for the positive inotropic effect of OPC-8212, a new positive inotropic agent, in single ventricular cells of the guinea pig heart.
  • T. Iijima, N. Taira
  • Biology, Medicine
    The Journal of pharmacology and experimental…
  • 1 February 1987
TLDR
It can be concluded that OPC-8212 augments the plateau and increases duration of the action potential not only by increasing the inward calcium but also by decreasing both the delayed outward and the inward-rectifying potassium current, and the effects can be a cause of the positive inotropic effect of this drug.
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