Plasminogen Activator

Known as: Plasminogen Activators, Plasminogen Activators [Chemical/Ingredient], activator plasminogen 
A heterogeneous group of proteolytic enzymes that convert PLASMINOGEN to FIBRINOLYSIN. They are concentrated in the lysosomes of most cells and in… (More)
National Institutes of Health

Related topics

Related topics

30 relations

Narrower (10)

ActilyseEminaseK1K2PuPla protease, Yersinia pestis
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Broader (4)

EndopeptidasesFibrinolytic AgentsSerine EndopeptidasesSerine Proteases
Endothelial CellsEnzyme GeneHydrolysisIn Blood
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Papers overview

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Highly Cited
2004
Highly Cited
2004
Increased oxidative stress in obesity and its impact on metabolic syndrome.
Obesity is a principal causative factor in the development of metabolic syndrome. Here we report that increased oxidative stress… (More)
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Highly Cited
2003
Highly Cited
2003
C-reactive protein increases plasminogen activator inhibitor-1 expression and activity in human aortic endothelial cells: implications for the metabolic syndrome and atherothrombosis.
BACKGROUND Inflammation plays a pivotal role in atherosclerosis. In addition to being a risk marker for cardiovascular disease… (More)
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Highly Cited
2002
Highly Cited
2002
Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study.
Elevated serum levels of acute-phase proteins, indicating chronic subclinical inflammation, have been associated with… (More)
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Highly Cited
2000
Highly Cited
2000
Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation.
The hexosamine pathway has been implicated in the pathogenesis of diabetic complications. We determined first that hyperglycemia… (More)
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Highly Cited
1998
Highly Cited
1998
Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene.
Smad proteins play a key role in the intracellular signalling of transforming growth factor beta (TGF beta), which elicits a… (More)
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Highly Cited
1998
Highly Cited
1998
High plasminogen activator inhibitor and tissue plasminogen activator levels in plasma precede a first acute myocardial infarction in both men and women: evidence for the fibrinolytic system as an…
BACKGROUND In patients with established ischemic heart disease, prospective cohort studies have indicated that plasminogen… (More)
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Highly Cited
1994
Highly Cited
1994
Physiological consequences of loss of plasminogen activator gene function in mice
Indirect evidence suggests a crucial role for the fibrinolytic system and its physiological triggers, tissue-type (t-PA) and… (More)
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Highly Cited
1985
Highly Cited
1985
Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarction.
Certain risk factors for myocardial infarction have been linked with disturbances in fibrinolytic activity. The recent… (More)
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Highly Cited
1985
Highly Cited
1985
A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase
The secretion of plasminogen activators has been implicated in the controlled extracellular proteolysis that accompanies cell… (More)
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Highly Cited
1974
Highly Cited
1974
SECRETION OF PLASMINOGEN ACTIVATOR BY STIMULATED MACROPHAGES
Cultured thioglycollate-stimulated peritoneal macrophages synthesize, accumulate, and continuously release high levels of… (More)
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