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Plasminogen Activator

Known as: Plasminogen Activators, Plasminogen Activators [Chemical/Ingredient], activator plasminogen 
A heterogeneous group of proteolytic enzymes that convert PLASMINOGEN to FIBRINOLYSIN. They are concentrated in the lysosomes of most cells and in… Expand
National Institutes of Health

Related topics

Related topics

31 relations

Narrower (11)

ActilyseEminaseK1K2PuPla protease, Yersinia pestis
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Broader (4)

EndopeptidasesFibrinolytic AgentsSerine EndopeptidasesSerine Proteases
Endothelial CellsEnzyme GeneHydrolysisIn Blood
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Endothelial dysfunction and platelet hyperactivity in type 2 diabetes mellitus: molecular insights and therapeutic strategies
The incidence and prevalence of diabetes mellitus is rapidly increasing worldwide at an alarming rate. Type 2 diabetes mellitus… Expand
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Highly Cited
2002
Highly Cited
2002
Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study.
Elevated serum levels of acute-phase proteins, indicating chronic subclinical inflammation, have been associated with… Expand
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Highly Cited
2000
Highly Cited
2000
Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation.
The hexosamine pathway has been implicated in the pathogenesis of diabetic complications. We determined first that hyperglycemia… Expand
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Highly Cited
1998
Highly Cited
1998
Direct binding of Smad3 and Smad4 to critical TGFβ‐inducible elements in the promoter of human plasminogen activator inhibitor‐type 1 gene
Smad proteins play a key role in the intracellular signalling of transforming growth factor β (TGFβ), which elicits a large… Expand
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Highly Cited
1994
Highly Cited
1994
Physiological consequences of loss of plasminogen activator gene function in mice
Indirect evidence suggests a crucial role for the fibrinolytic system and its physiological triggers, tissue-type (t-PA) and… Expand
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Highly Cited
1994
Highly Cited
1994
An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct.
Transforming growth factor-beta (TGF-beta) is a potent regulator of cellular differentiation, proliferation, migration, and… Expand
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Review
1985
Review
1985
Plasminogen activators, tissue degradation, and cancer.
Publisher Summary This chapter discusses the role of plasminogen activators in various biological processes. In specific, it… Expand
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Highly Cited
1983
Highly Cited
1983
Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli
Bacterial clones containing human tissue-type plasminogen activator (t-PA) cDNA sequences were identified in a cDNA library… Expand
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Highly Cited
1982
Highly Cited
1982
Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin.
The kinetics of the activation of Glu-plasminogen and Lys-plasminogen (P) by a two-chain form of human tissue plasminogen… Expand
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Highly Cited
1980
Highly Cited
1980
Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates.
Abstract A new technique is described for the electrophoretic analysis of plasminogen activators in sodium dodecyl sulfate… Expand
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