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Plasminogen Activator
Known as:
Plasminogen Activators
, Plasminogen Activators [Chemical/Ingredient]
, activator plasminogen
A heterogeneous group of proteolytic enzymes that convert PLASMINOGEN to FIBRINOLYSIN. They are concentrated in the lysosomes of most cells and in…
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National Institutes of Health
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Related topics
Related topics
31 relations
Narrower (11)
Actilyse
Eminase
K1K2Pu
Pla protease, Yersinia pestis
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Broader (4)
Endopeptidases
Fibrinolytic Agents
Serine Endopeptidases
Serine Proteases
Endothelial Cells
Enzyme Gene
Hydrolysis
In Blood
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study.
A. Festa
,
R. D'Agostino
,
R. Tracy
,
S. Haffner
Diabetes
2002
Corpus ID: 17851285
Elevated serum levels of acute-phase proteins, indicating chronic subclinical inflammation, have been associated with…
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Review
2001
Review
2001
Role of the Matrix Metalloproteinase and Plasminogen Activator-Plasmin Systems in Angiogenesis
M. Pepper
Arteriosclerosis, thrombosis, and vascular…
2001
Corpus ID: 23663847
Abstract—Extracellular proteolysis is an absolute requirement for new blood vessel formation (angiogenesis). This review examines…
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Highly Cited
2000
Highly Cited
2000
Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation.
X. Du
,
D. Edelstein
,
+5 authors
M. Brownlee
Proceedings of the National Academy of Sciences…
2000
Corpus ID: 84095
The hexosamine pathway has been implicated in the pathogenesis of diabetic complications. We determined first that hyperglycemia…
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Highly Cited
1998
Highly Cited
1998
Direct binding of Smad3 and Smad4 to critical TGFβ‐inducible elements in the promoter of human plasminogen activator inhibitor‐type 1 gene
S. Dennler
,
S. Itoh
,
D. Vivien
,
P. ten Dijke
,
S. Huet
,
J. Gauthier
The EMBO journal
1998
Corpus ID: 30415532
Smad proteins play a key role in the intracellular signalling of transforming growth factor β (TGFβ), which elicits a large…
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Highly Cited
1994
Highly Cited
1994
Physiological consequences of loss of plasminogen activator gene function in mice
P. Carmeliet
,
L. Schoonjans
,
+7 authors
R. Mulligan
Nature
1994
Corpus ID: 4348866
Indirect evidence suggests a crucial role for the fibrinolytic system and its physiological triggers, tissue-type (t-PA) and…
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Review
1985
Review
1985
Plasminogen activators, tissue degradation, and cancer.
K. Danø
,
P. Andreasen
,
J. Grøndahl‐Hansen
,
P. Kristensen
,
L. Nielsen
,
L. Skriver
Advances in cancer research
1985
Corpus ID: 789011
Highly Cited
1985
Highly Cited
1985
Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarction.
A. Hamsten
,
B. Wiman
,
U. de Faire
,
M. Blombäck
The New England journal of medicine
1985
Corpus ID: 19396621
Certain risk factors for myocardial infarction have been linked with disturbances in fibrinolytic activity. The recent…
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Highly Cited
1983
Highly Cited
1983
Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli
D. Pennica
,
W. Holmes
,
+9 authors
D. Collen
Nature
1983
Corpus ID: 39846803
Bacterial clones containing human tissue-type plasminogen activator (t-PA) cDNA sequences were identified in a cDNA library…
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Highly Cited
1982
Highly Cited
1982
Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin.
M. Hoylaerts
,
D. Rijken
,
H. Lijnen
,
D. Collen
The Journal of biological chemistry
1982
Corpus ID: 21960788
The kinetics of the activation of Glu-plasminogen and Lys-plasminogen (P) by a two-chain form of human tissue plasminogen…
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Highly Cited
1980
Highly Cited
1980
Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates.
C. Heussen
,
E. Dowdle
Analytical biochemistry
1980
Corpus ID: 5887587
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