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Plasminogen Activator

Known as: Plasminogen Activators, Plasminogen Activators [Chemical/Ingredient], activator plasminogen 
A heterogeneous group of proteolytic enzymes that convert PLASMINOGEN to FIBRINOLYSIN. They are concentrated in the lysosomes of most cells and in… 
National Institutes of Health

Related topics

Related topics

31 relations

Narrower (11)

ActilyseEminaseK1K2PuPla protease, Yersinia pestis
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Broader (4)

EndopeptidasesFibrinolytic AgentsSerine EndopeptidasesSerine Proteases
Endothelial CellsEnzyme GeneHydrolysisIn Blood
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study.
Elevated serum levels of acute-phase proteins, indicating chronic subclinical inflammation, have been associated with… 
Review
2001
Review
2001
Role of the Matrix Metalloproteinase and Plasminogen Activator-Plasmin Systems in Angiogenesis
  • M. Pepper
  • Arteriosclerosis, thrombosis, and vascular…
  • 2001
  • Corpus ID: 23663847
Abstract—Extracellular proteolysis is an absolute requirement for new blood vessel formation (angiogenesis). This review examines… 
Highly Cited
2000
Highly Cited
2000
Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation.
The hexosamine pathway has been implicated in the pathogenesis of diabetic complications. We determined first that hyperglycemia… 
Highly Cited
1998
Highly Cited
1998
Direct binding of Smad3 and Smad4 to critical TGFβ‐inducible elements in the promoter of human plasminogen activator inhibitor‐type 1 gene
Smad proteins play a key role in the intracellular signalling of transforming growth factor β (TGFβ), which elicits a large… 
Highly Cited
1994
Highly Cited
1994
Physiological consequences of loss of plasminogen activator gene function in mice
Indirect evidence suggests a crucial role for the fibrinolytic system and its physiological triggers, tissue-type (t-PA) and… 
Review
1985
Review
1985
Plasminogen activators, tissue degradation, and cancer.
Highly Cited
1985
Highly Cited
1985
Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarction.
Certain risk factors for myocardial infarction have been linked with disturbances in fibrinolytic activity. The recent… 
Highly Cited
1983
Highly Cited
1983
Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli
Bacterial clones containing human tissue-type plasminogen activator (t-PA) cDNA sequences were identified in a cDNA library… 
Highly Cited
1982
Highly Cited
1982
Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin.
The kinetics of the activation of Glu-plasminogen and Lys-plasminogen (P) by a two-chain form of human tissue plasminogen… 
Highly Cited
1980
Highly Cited
1980
Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates.
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