Physiological consequences of loss of plasminogen activator gene function in mice

@article{Carmeliet1994PhysiologicalCO,
  title={Physiological consequences of loss of plasminogen activator gene function in mice},
  author={Peter Carmeliet and Luc Schoonjans and Lena Kieckens and Beverly Ream and Jay L. Degen and Roderick Bronson and Rita Vos and Joost J. van den Oord and D{\'e}sir{\'e} Collen and Richard c. Mulligan},
  journal={Nature},
  year={1994},
  volume={368},
  pages={419-424}
}
Indirect evidence suggests a crucial role for the fibrinolytic system and its physiological triggers, tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activator, in many proteolytic processes. Inactivation of the t-PA gene impairs clot lysis and inactivation of the u-PA gene results in occasional fibrin deposition. Mice with combined t-PA and u-PA deficiency suffer extensive spontaneous fibrin deposition, with its associated effects on growth, fertility and survival. 
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