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New functions for the matrix metalloproteinases in cancer progression
It is shown that the MMPs have functions other than promotion of invasion, have substrates other than components of the extracellular matrix, and that they function before invasion in the development of cancer.
Lifeact: a versatile marker to visualize F-actin
Lifeact, a 17-amino-acid peptide, is described, which stained filamentous actin (F-actin) structures in eukaryotic cells and tissues and in its chemically modified peptide form allowed visualization of actin dynamics in nontransfectable cells.
How matrix metalloproteinases regulate cell behavior.
Recent advances shed light on how the structure and function of the MMPs are related and on how their transcription, secretion, activation, inhibition, localization, and clearance are controlled.
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
The results show that MMP-9 is a component of theAngiogenic switch, and MMP inhibitors reduce angiogenic switching, and tumour number and growth, as does genetic ablation of M MP-9.
Matrix metalloproteinases and the regulation of tissue remodelling
Recent studies in mice and flies point to essential roles of MMPs as mediators of change and physical adaptation in tissues, whether developmentally regulated, environmentally induced or disease associated.
Remodelling the extracellular matrix in development and disease
The extracellular matrix is crucial for regulating the morphogenesis of the intestine and lungs, as well as of the mammary and submandibular glands, and its regulation contributes to several pathological conditions, such as fibrosis and invasive cancer.
VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
- H. Gerber, T. Vu, A. Ryan, J. Kowalski, Z. Werb, N. Ferrara
- Biology, MedicineNature Medicine
- 1 June 1999
It is shown that VEGF-mediated capillary invasion is an essential signal that regulates growth plate morphogenesis and triggers cartilage remodeling and VEGf is anessential coordinator of chondrocyte death, chondROclast function, extracellular matrix remodeling, angiogenesis and bone formation in the growth plate.
Netting neutrophils in autoimmune small-vessel vasculitis
It is shown that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 and myeloperoxidase (MPO).
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
These findings identify a previously undescribed pathway in which a component of the breast tumour microenvironment alters cellular structure in culture and tissue structure in vivo, leading to malignant transformation.