Z. Werb

Publications584
h-index165
Citations111,959
Highly Influential Citations4,489
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New functions for the matrix metalloproteinases in cancer progression
Matrix metalloproteinases (MMPs) have long been associated with cancer-cell invasion and metastasis. This provided the rationale for clinical trials of MMP inhibitors, unfortunately with… Expand
Lifeact: a versatile marker to visualize F-actin
Live imaging of the actin cytoskeleton is crucial for the study of many fundamental biological processes, but current approaches to visualize actin have several limitations. Here we describe Lifeact,… Expand
How matrix metalloproteinases regulate cell behavior.
The matrix metalloproteinases (MMPs) constitute a multigene family of over 25 secreted and cell surface enzymes that process or degrade numerous pericellular substrates. Their targets include other… Expand
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
Extracellular proteolysis mediates tissue homeostasis. In cancer, altered proteolysis leads to unregulated tumor growth, tissue remodeling, inflammation, tissue invasion, and metastasis. The matrix… Expand
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
During carcinogenesis of pancreatic islets in transgenic mice, an angiogenic switch activates the quiescent vasculature. Paradoxically, vascular endothelial growth factor (VEGF) and its receptors are… Expand
Matrix metalloproteinases and the regulation of tissue remodelling
Matrix metalloproteinases (MMPs) were discovered because of their role in amphibian metamorphosis, yet they have attracted more attention because of their roles in disease. Despite intensive scrutiny… Expand
VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
Hypertrophic chondrocytes in the epiphyseal growth plate express the angiogenic protein vascular endothelial growth factor (VEGF). To determine the role of VEGF in endochondral bone formation, we… Expand
Netting neutrophils in autoimmune small-vessel vasculitis
Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to antineutrophil cytoplasm autoantibodies (ANCAs). Here we show that chromatin fibers, so-called neutrophil extracellular… Expand
Remodelling the extracellular matrix in development and disease
The extracellular matrix (ECM) is a highly dynamic structure that is present in all tissues and continuously undergoes controlled remodelling. This process involves quantitative and qualitative… Expand
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
The tumour microenvironment can be a potent carcinogen, not only by facilitating cancer progression and activating dormant cancer cells, but also by stimulating tumour formation. We have previously… Expand
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