• Publications
  • Influence
Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein.
The regulation of cerebrovascular permeability is critical for normal brain homeostasis, and the "breakdown" of the blood-brain barrier (BBB) is associated with the development of vasogenic edema andExpand
  • 477
  • 34
  • Open Access
An Extracellular Proteolytic Cascade Promotes Neuronal Degeneration in the Mouse Hippocampus
Mice lacking the serine protease tissue plasminogen activator (tPA) are resistant to excitotoxin-mediated hippocampal neuronal degeneration. We have used genetic and cellular analyses to study theExpand
  • 408
  • 15
  • Open Access
Proteolytic Activation of the 1918 Influenza Virus Hemagglutinin
ABSTRACT Proteolytic activation of the hemagglutinin (HA) protein is indispensable for influenza virus infectivity, and the tissue expression of the responsible cellular proteases impacts viralExpand
  • 187
  • 14
Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells.
Detailed studies of tumor cell-associated procoagulants and fibrinolytic factors have implied that local thrombin generation and fibrin deposition and dissolution may be important in tumor growth andExpand
  • 493
  • 13
Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.
Plasminogen (Plg)-deficient mice were generated to define the physiological roles of this key fibrinolytic protein and its proteolytic derivatives, plasmin and angiostatin, in development,Expand
  • 409
  • 13
Loss of Fibrinogen Rescues Mice from the Pleiotropic Effects of Plasminogen Deficiency
Plasmin(ogen) is an extracellular serine protease implicated in the activation of latent growth factors and procollagenase, degradation of extracellular matrix components, and fibrin clearance.Expand
  • 379
  • 13
Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation.
Overexpression of the type II transmembrane serine protease matriptase is a highly consistent feature of human epithelial tumors. Here we show that matriptase possesses a strong oncogenic potentialExpand
  • 223
  • 13
Fibrin and fibrinolysis in infection and host defense
Summary.  Bacterial pathogens have frequently evolved and maintained the capacity to engage and/or activate hemostatic system components of their vertebrate hosts. Recent studies of mice withExpand
  • 160
  • 13
Membrane anchored serine proteases: A rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer
Dysregulated proteolysis is a hallmark of cancer. Malignant cells require a range of proteolytic activities to enable growth, survival, and expansion. Serine proteases of the S1 or trypsin-likeExpand
  • 277
  • 12
Plasminogen Is Required for Efficient Dissemination of B. burgdorferi in Ticks and for Enhancement of Spirochetemia in Mice
The role of the host plasminogen activation system in transmission of and invasion by Borrelia burgdorferi, the tick-borne spirochetal agent of Lyme disease, was investigated using plasminogenExpand
  • 324
  • 11