Skip to search formSkip to main contentSkip to account menu

PTPRC gene

Known as: GP180, CD45, T200 GLYCOPROTEIN 
This gene plays a role in suppression of cytokine receptor signaling and the regulation of signal transduction in lymphocytes.
National Institutes of Health

Related topics

Related topics

13 relations
CD45 AntigensCD45RA AntigensCD45RB, humanCD45RC

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1998
Highly Cited
1998
Mouse resident microglia: Isolation and characterization of immunoregulatory properties with naïve CD4+ and CD8+ T‐cells
We describe a non‐enzymatic procedure designed to isolate in high purity resident microglia from the brains of normal mice. This… 
Highly Cited
1995
Highly Cited
1995
Modulation of T-cell adhesion markers, and the CD45R and CD57 antigens in human alcoholics.
Direct and indirect evidence indicates that T cells are altered in alcoholics. The most commonly reported changes under direct… 
Highly Cited
1992
Highly Cited
1992
Activation requirements for CD4+ T cells differing in CD45R expression.
Murine CD4+ T cells can be subdivided into naive and memory T cells based on surface phenotype, on recall response to Ag, and on… 
Review
1989
Review
1989
Leukocyte cell surface enzymology: CD45 (LCA, T200) is a protein tyrosine phosphatase.
Highly Cited
1988
Highly Cited
1988
Loss of CD45R (Lp220) represents a post-thymic T cell differentiation event.
CD45R+ and CDw29+ CD4+ T cells are widely regarded as separate functionally defined T cell lineages. The work described here… 
Highly Cited
1988
Highly Cited
1988
Two subsets of human CD4+T helper cells differing in kinetics and capacities to produce interleukin 2 and interferon‐γ can be defined by the Leu‐18 and UCHLl monoclonal antibodies
Human CD4   + T helper cells were separated into CD4+45R+and CD4+45R− cells. When stimulated with the polyclonal activator… 
Review
1987
Review
1987
Human T cell subsets.
Highly Cited
1986
Highly Cited
1986
Induction of immune tolerance by administration of monoclonal antibody to L3T4.
Immune responses can be profoundly altered in mice by treatment with monoclonal antibodies (MAb) to L3T4, the mouse homologue for… 
Highly Cited
1985
Highly Cited
1985
Antibodies to common leukocyte antigen p220 influence human T cell proliferation by modifying IL 2 receptor expression.
The p220 antigen is found on the high m.w. form of the T200 common leukocyte antigen family. Although T200 monoclonal antibodies… 
Highly Cited
1978
Highly Cited
1978
Participation of histocompatibility antigens in capping of molecularly independent cell surface components by their specific antibodies.
The antibody-induced capping of several cell surface components has been investigated by immunofluorescence methods using two… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)