PTPRC gene

Known as: GP180, CD45, T200 GLYCOPROTEIN 
This gene plays a role in suppression of cytokine receptor signaling and the regulation of signal transduction in lymphocytes.

Topic mentions per year

Topic mentions per year

1974-2018
0204019742018

Papers overview

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Highly Cited
2004
Highly Cited
2004
The generation of B lymphocyte precursors is dependent on the combinatorial action of the transcription factors PU.1, Ikaros, E2A… (More)
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Highly Cited
2002
Highly Cited
2002
We have biologically characterized two new members of the IL-17 cytokine family: IL-17F and IL-25. In contrast to conventional in… (More)
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Highly Cited
2001
Highly Cited
2001
Interferon alpha/beta plays an important role in the first-line defense against viral infections and can modulate cytokine… (More)
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Highly Cited
1996
Highly Cited
1996
The mature, resting immunoglobulin (Ig) M, IgD+ B lymphocyte can be induced by T cells to proliferate, switch isotype, and… (More)
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Highly Cited
1996
Highly Cited
1996
We have identified a very early stage of B lineage cells in the CD45R (B220)+CD24 (HSA) pre-pro-B fraction of mouse bone marrow… (More)
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Highly Cited
1990
Highly Cited
1990
A new panel of mAbs was prepared to a stromal cell line known to support lymphocytes in Whitlock-Witte type long-term bone marrow… (More)
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Highly Cited
1990
Highly Cited
1990
It has been proposed that the skin is a functionally unique compartment of the immune system, although little direct evidence… (More)
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Highly Cited
1989
Highly Cited
1989
In the present study we have identified and characterized three subpopulations of peripheral blood NK cells based on the surface… (More)
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Highly Cited
1988
Highly Cited
1988
A group of mAb recognizing the 200- and/or 220-kDa determinants (CD45R) of the leukocyte common Ag such as 2H4, WR16, MD4.3, and… (More)
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Highly Cited
1982
Highly Cited
1982
The first part of this article discusses the isolation and characterization of several monoclonal antibodies to the B lineage… (More)
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