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CD45RB, human

Known as: CD45RB, CD45RB Antigen, Receptor-Type Tyrosine-Protein Phosphatase C Isoform CD45RB 
CD45RB is encoded by the human PTPRC gene. This protein is involved in both protein dephosphorylation and lymphocyte activity. It is an isoform of… 
National Institutes of Health

Related topics

Related topics

11 relations
DephosphorylationEnzyme GeneEsterase GeneHydrolase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Prolonged survival of rat islet xenografts in mice after CD45RB monotherapy
Background. Pancreatic islet transplantation can correct the disordered glucose metabolism of type 1 diabetes, but the number of… 
2004
2004
Novel Duchenne Muscular Dystrophy Treatment Through Myoblast Transplantation Tolerance with Anti‐CD45RB, Anti‐CD154 and Mixed Chimerism
Duchenne muscular dystrophy (DMD) is a fatal disease caused by a defect in the skeletal muscle protein, dystrophin. One potential… 
2003
2003
CD45RB-targeting strategies for promoting long-term allograft survival and preventingchronic allograft vasculopathy1
Background. CD45RB is a potent immunomodulatory target to achieve long-term allograft survival. We evaluated the in vivo effect… 
Highly Cited
2001
Highly Cited
2001
Targeting Signal 1 Through CD45RB Synergizes with CD40 Ligand Blockade and Promotes Long Term Engraftment and Tolerance in Stringent Transplant Models1
The induction and maintenance of allograft tolerance is a daunting challenge. Although combined blockade of CD28 and CD40 ligand… 
Highly Cited
2001
Highly Cited
2001
CTLA-4 up-regulation plays a role in tolerance mediated by CD45
Highly Cited
2001
Highly Cited
2001
Careers in immunology: the new reality
Cytolytic T lymphocyte–associated antigen 4 (CTLA-4) is a critical down-regulatory molecule in T cells that plays a major role in… 
1999
1999
Adoptively transferable tolerance induced by CD45RB monoclonal antibody.
The phenomenon of rejection remains the most serious problem in transplantation. The ultimate goal in transplant immunology is to… 
1999
1999
Mechanisms of induction of renal allograft tolerance in CD45RB-treated mice.
BACKGROUND Rejection is the most significant problem in the field of transplantation. The current goal of transplant immunology… 
1998
1998
Prevention of experimental allergic encephalomyelitis by an antibody to CD45RB.
CD45 is involved in the regulation of lymphocyte activation, and it has been demonstrated that ligation of CD45 induces apoptosis… 
Highly Cited
1994
Highly Cited
1994
Selective enrichment of Th1 CD45RBlow CD4+ T cells in autoimmune infiltrates in experimental allergic encephalomyelitis.
The cytokine effector status of CD4+ T cells from lymph nodes (LN) and the central nervous system (CNS) of SJL/J mice immunized… 
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