• Publications
  • Influence
CD44 and its interaction with extracellular matrix.
It is now generally accepted that CD44 is a cell adhesion receptor and that hyaluronan is one of its ligands. Like many cell adhesion receptors, CD44 is broadly distributed, and its ligand,Expand
  • 1,088
  • 41
Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow.
Viable Lin(-) CD27(+) c-kit(Hi) Sca-1(Hi) GFP(+) cells recovered from heterozygous RAG1/GFP knockin mice progressed through previously defined stages of B, T, and NK cell lineage differentiation. InExpand
  • 503
  • 38
Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment.
Toll-like receptors (TLRs) are best known for their ability to recognize microbial or viral components and initiate innate immune responses. We showed here that TLRs and their coreceptors wereExpand
  • 667
  • 32
Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long- term bone marrow cultures
A new panel of mAbs was prepared to a stromal cell line known to support lymphocytes in Whitlock-Witte type long-term bone marrow cultures. These antibodies were then screened with a cell adhesionExpand
  • 582
  • 18
  • PDF
Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition
A cell adhesion model was previously used to select a series of monoclonal antibodies (mAbs), which were subsequently found to recognize CD44/Pgp-1. Interest in these reagents increased with theExpand
  • 635
  • 17
  • PDF
Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis
Adhesion molecules are probably required for retention of maturing lymphocyte precursors in bone marrow, where they closely interact with and are dependent on stromal cells. Lymphomyeloid cell linesExpand
  • 619
  • 16
  • PDF
Requirements for hyaluronic acid binding by CD44: a role for the cytoplasmic domain and activation by antibody
The CD44-negative T lymphoma AKR1 (CD44.2 genotype) was transfected with a CD44.1 cDNA. The intact cDNA conferred on the transfected cells the ability to bind hyaluronic acid (HA) both from solutionExpand
  • 259
  • 15
  • PDF
Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine fertilization.
  • M. Chen, K. Tung, +7 authors J. White
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 12 October 1999
CD9 is a tetraspan protein that associates with several beta1 integrins, including alpha6beta1. Because alpha6beta1 is present on murine eggs and interacts with the sperm-surface glycoprotein ADAM 2Expand
  • 202
  • 15
The protean nature of cells in the B lymphocyte lineage.
The subdivision of bone marrow (BM) with surface markers and reporter systems and the use of multiple culture and transplantation assays to assess differentiation potential have led to extraordinaryExpand
  • 243
  • 15
Chronic Exposure to a TLR Ligand Injures Hematopoietic Stem Cells
Hematopoietic stem cells (HSC) can be harmed by disease, chemotherapy, radiation, and normal aging. We show in this study that damage also occurs in mice repeatedly treated with very low doses ofExpand
  • 199
  • 14