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PTK2B gene

Known as: PROTEIN-TYROSINE KINASE 2, BETA, FAK2, FOCAL ADHESION KINASE 2 
This gene is involved in signal transduction and the regulation of ion channels.
National Institutes of Health

Related topics

Related topics

13 relations
ApoptosisCell Differentiation processCell ProliferationHomo sapiens

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PTK2B wt Allele

Papers overview

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Highly Cited
2001
Highly Cited
2001
A role for PYK2 in regulation of ERK1/2 MAP kinases and PI 3-kinase by ANG II in vascular smooth muscle.
Abnormal vascular smooth muscle cell (VSMC) growth plays a key role in the pathogenesis of hypertension and atherosclerosis… 
Highly Cited
2000
Highly Cited
2000
Cerebral Ischemia and Seizures Induce Tyrosine Phosphorylation of PYK2 in Neurons and Microglial Cells
The nonreceptor tyrosine kinase PYK2 represents a stress-sensitive mediator of c-Jun N-terminal kinase and p38 mitogen-activated… 
Highly Cited
1999
Highly Cited
1999
Identification of a Novel Family of Targets of PYK2 Related to Drosophila Retinal Degeneration B (rdgB) Protein
ABSTRACT The protein tyrosine kinase PYK2 has been implicated in signaling pathways activated by G-protein-coupled receptors… 
Highly Cited
1998
Highly Cited
1998
Activation of protein tyrosine kinase PYK2 by the m1 muscarinic acetylcholine receptor.
Several G protein-coupled receptors are known to direct the tyrosine phosphorylation, and in some cases the activation, of… 
Highly Cited
1998
Highly Cited
1998
A Calcium-dependent Tyrosine Kinase Splice Variant in Human Monocytes
Freshly isolated human monocytes do not express p125FAK but upon adherence to substrata activate the highly related calcium… 
Highly Cited
1998
Highly Cited
1998
Leupaxin Is a Novel LIM Domain Protein That Forms a Complex with PYK2*
We have identified a novel cytoplasmic protein, leupaxin, that is preferentially expressed in hematopoietic cells and is most… 
Highly Cited
1997
Highly Cited
1997
Tyrosine Phosphorylation of Pyk2 Is Selectively Regulated by Fyn During TCR Signaling
The Src family protein tyrosine kinases (PTKs), Lck and Fyn, are coexpressed in T cells and perform crucial functions involved in… 
Highly Cited
1997
Highly Cited
1997
Paxillin Is Tyrosine-phosphorylated by and Preferentially Associates with the Calcium-dependent Tyrosine Kinase in Rat Liver Epithelial Cells*
We and others have recently cloned a non-receptor, calcium-dependent tyrosine kinase (CADTK; also known as PYK2, CAKβ, and RAFTK… 
Highly Cited
1996
Highly Cited
1996
Activation of a Novel Calcium-dependent Protein-tyrosine Kinase
Many G protein-coupled receptors (e.g. that of angiotensin II) activate phospholipase Cβ, initially increasing intracellular… 
Highly Cited
1996
Highly Cited
1996
Characterization of RAFTK, a novel focal adhesion kinase, and its integrin-dependent phosphorylation and activation in megakaryocytes.
We have recently isolated a cDNA encoding a novel human intracellular tyrosine kinase, termed RAFTK (for a related adhesion focal… 
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