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PTK2B wt Allele

Known as: Cell Adhesion Kinase, Beta Gene, FAK2, PTK2B Protein Tyrosine Kinase 2 Beta Gene 
Human PTK2B wild-type allele is located in the vicinity of 8p21.1 and is approximately 148 kb in length. This allele, which encodes protein tyrosine… 
National Institutes of Health

Related topics

Related topics

20 relations
8p21.1Angiotensin II Signaling PathwayApoptosisCCR5 Signaling Pathway

Broader (1)

PTK2B gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Soluble markers for the assessment of biological activity with PTK787/ZK 222584 (PTK/ZK), a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor in patients with advanced…
BACKGROUND Plasma and serum biomarkers of angiogenesis and activated endothelial cells were evaluated to assess biological… 
2005
2005
Role of the Actin Cytoskeleton in G-Protein–Coupled Receptor Activation of PYK2 and Paxillin in Vascular Smooth Muscle
Dynamic remodeling of the actin cytoskeleton occurs during agonist-induced smooth muscle contraction. Tyrosine phosphorylation of… 
Review
2004
Review
2004
A phase I/II trial of single-agent PTK 787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in patients with recurrent glioblastoma multiforme (GBM).
1512 Background: VEGF-mediated signaling pathways may be critical to GBM neovascularization, and inhibition of VEGF pathways may… 
Highly Cited
2004
Highly Cited
2004
A phase I/II trial of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with either temozolomide or lomustine for patients with recurrent glioblastoma multiforme (GBM).
1513 Background: VEGF-mediated signaling through VEGF receptors is integral to GBM neovascularization and therefore an attractive… 
Highly Cited
2004
Highly Cited
2004
Phase I/II study of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor in combination with FOLFIRI as first-line treatment for patients with metastatic colorectal cancer.
3558 Background: Increased angiogenesis is correlated with poor prognosis in patients with advanced metastatic colorectal cancer… 
Highly Cited
2000
Highly Cited
2000
The Requirement of Both Extracellular Regulated Kinase and p38 Mitogen-activated Protein Kinase for Stimulation of Cytosolic Phospholipase A2 Activity by Either FcγRIIA or FcγRIIIB in Human…
The signal transduction pathways initiated by opsonized zymosan (OZ) leading to activation of cytosolic phospholipase A2 (cPLA2… 
2000
2000
High‐frequency synaptic stimulation induces association of fyn and c‐src to distinct phosphorylated components
Signaling via tyrosine kinases appears necessary for regulation of synaptic efficacy. Interactions of the src-family kinases with… 
Highly Cited
1998
Highly Cited
1998
Activation of protein tyrosine kinase PYK2 by the m1 muscarinic acetylcholine receptor.
Several G protein-coupled receptors are known to direct the tyrosine phosphorylation, and in some cases the activation, of… 
Highly Cited
1997
Highly Cited
1997
Tyrosine Phosphorylation of Pyk2 Is Selectively Regulated by Fyn During TCR Signaling
The Src family protein tyrosine kinases (PTKs), Lck and Fyn, are coexpressed in T cells and perform crucial functions involved in… 
Highly Cited
1996
Highly Cited
1996
Molecular cloning and assignment of FAK2, a novel human focal adhesion kinase, to 8p11.2-p22 by nonisotopic in situ hybridization.
This report describes the localization of a novel human focal adhesion kinase, FAK2, to human chromosome 8p11.2-p22 using in situ… 
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