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Signal transduction by lymphocyte antigen receptors
Insight gained from studies of the signaling pathways downstream of TCR and BCR stimulation is likely to contribute significantly to future understanding of mechanisms responsible for lymphocyte differentiation and for the discrimination of self from nonself in developing and mature cells. Expand
ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia.
Although the presence of an unmutated IgV(H) gene is strongly associated with the expression of Zap-70, ZAP-70 is a stronger predictor of the need for treatment in B-cell CLL. Expand
Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor
Results indicate that lck is required for normal signal transduction through the TCR, and expression of the lck cDNA in JCaM1 restores the ability of the cell to respond to TCR stimulation. Expand
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
Animal models and cell line studies both indicate a critical role for Lck and Fyn in proximal T-cell antigen receptor (TCR) signal transduction, and SFKs are required for each of these TCR-based signals, and Lck seems to be the major contributor. Expand
CD45: a critical regulator of signaling thresholds in immune cells.
A model is emerging in which CD45 affects cellular responses by controlling the relative threshold of sensitivity to external stimuli, and recent advances suggest that modulation of CD45 function can have therapeutic benefit in many disease states. Expand
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.
The T cell antigen receptor (TCR) initiates signals by interacting with cytoplasmic protein tyrosine kinases (PTKs) through a 17-residue sequence motif [called the antigen recognition activationExpand
Activation of the innate immune receptor Dectin-1 upon formation of a “phagocytic synapse”
The ‘phagocytic synapse’ now provides a model mechanism by which innate immune receptors can distinguish direct microbial contact from detection of microbes at a distance, thereby initiating direct cellular antimicrobial responses only when they are required. Expand
Induction of NF-kappaB by the Akt/PKB kinase.
It is shown that Akt can regulate signaling pathways that lead to induction of the NF-kappaB family of transcription factors in the Jurkat T-cell line, uncovering a previously unappreciated connection between Akt and NF- kappaB induction that could have implications for the control of T- cell growth and survival. Expand
Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28.
St Stimulation of CD28, a molecule expressed on most human T cells, induced the formation of a protein complex that bound to a site on the IL-2 gene distinct from previously described binding sites and increasedIL-2 enhancer activity fivefold. Expand
Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia.
Examining isolated leukemia B cells of patients with chronic lymphocytic leukemia for expression of zeta-associated protein 70 indicates that expression of ZAP-70 is associated with enhanced signal transduction via the BCR complex, which may contribute to the more aggressive clinical course associated with CLL cells that express nonmutated immunoglobulin receptors. Expand