Signal transduction by lymphocyte antigen receptors
ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia.
Although the presence of an unmutated IgV(H) gene is strongly associated with the expression of Zap-70, ZAP-70 is a stronger predictor of the need for treatment in B-cell CLL.
Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor
CD45: a critical regulator of signaling thresholds in immune cells.
A model is emerging in which CD45 affects cellular responses by controlling the relative threshold of sensitivity to external stimuli, and recent advances suggest that modulation of CD45 function can have therapeutic benefit in many disease states.
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
Animal models and cell line studies both indicate a critical role for Lck and Fyn in proximal T-cell antigen receptor (TCR) signal transduction, and SFKs are required for each of these TCR-based signals, and Lck seems to be the major contributor.
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.
The T cell antigen receptor (TCR) initiates signals by interacting with cytoplasmic protein tyrosine kinases (PTKs) through a 17-residue sequence motif [called the antigen recognition activation…
Activation of the innate immune receptor Dectin-1 upon formation of a “phagocytic synapse”
The ‘phagocytic synapse’ now provides a model mechanism by which innate immune receptors can distinguish direct microbial contact from detection of microbes at a distance, thereby initiating direct cellular antimicrobial responses only when they are required.
Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia.
Examining isolated leukemia B cells of patients with chronic lymphocytic leukemia for expression of zeta-associated protein 70 indicates that expression of ZAP-70 is associated with enhanced signal transduction via the BCR complex, which may contribute to the more aggressive clinical course associated with CLL cells that express nonmutated immunoglobulin receptors.
ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain.
The isolation of a cDNA clone encoding ZAP-70 represents a novel PTK that associates with zeta and undergoes tyrosine phosphorylation following TCR stimulation and provide a potential mechanism by which the src family PTKs and Zap-70 may interact to mediate TCR signal transduction.
Jurkat T cells and development of the T-cell receptor signalling paradigm
Some of the key advances in the field of TCR signalling that were made with Jurkat T cells as the host are reviewed.