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Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions
The protein tyrosine kinase PYK2, which is highly expressed in the central nervous system, is rapidly phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular… Expand
A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation
THE mechanisms by which mitogenic G-protein-coupled receptors activate the MAP kinase signalling pathway are poorly understood. Candidate protein tyrosine kinases that link G-protein-coupled… Expand
RNA interference screen for human genes associated with West Nile virus infection
West Nile virus (WNV), and related flaviviruses such as tick-borne encephalitis, Japanese encephalitis, yellow fever and dengue viruses, constitute a significant global human health problem. However,… Expand
Coordinated lipid transfer between the endoplasmic reticulum and the Golgi complex requires the VAP proteins and is essential for Golgi-mediated transport.
- Diego Peretti, Nili Dahan, E. Shimoni, K. Hirschberg, S. Lev
- Biology, Medicine
- Molecular biology of the cell
- 1 September 2008
Lipid transport between intracellular organelles is mediated by vesicular and nonvesicular transport mechanisms and is critical for maintaining the identities of different cellular membranes.… Expand
Activation of Pyk2 by Stress Signals and Coupling with JNK Signaling Pathway
The c-Jun amino-terminal kinase (JNK) is activated by various heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors, inflammatory cytokines, and stress signals. Yet,… Expand
The VAP protein family: from cellular functions to motor neuron disease.
The VAMP-associated proteins (VAPs) are highly conserved integral endoplasmic reticulum membrane proteins implicated in diverse cellular functions, including the regulation of lipid transport and… Expand
Differential Regulation of Endoplasmic Reticulum Structure through VAP-Nir Protein Interaction*
- Roy Amarilio, Sree Ramachandran, H. Sabanay, S. Lev
- Medicine, Biology
- Journal of Biological Chemistry
- 18 February 2005
The endoplasmic reticulum (ER) exhibits a characteristic tubular structure that is dynamically rearranged in response to specific physiological demands. However, the mechanisms by which the ER… Expand
Non-vesicular lipid transport by lipid-transfer proteins and beyond
- S. Lev
- Biology, Medicine
- Nature Reviews Molecular Cell Biology
- 1 October 2010
The movement of lipids within and between intracellular membranes is mediated by different lipid transport mechanisms and is crucial for maintaining the identities of different cellular organelles.… Expand
Tethering the assembly of SNARE complexes.
The fusion of transport vesicles with their target membranes is fundamental for intracellular membrane trafficking and diverse physiological processes and is driven by the assembly of functional… Expand
Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing
The crucial roles of Sec1/Munc18 (SM)‐like proteins in membrane fusion have been evidenced in genetic and biochemical studies. SM proteins interact directly with SNAREs and contribute to SNARE… Expand