Guidelines for the use and interpretation of assays for monitoring autophagy
- D. Klionsky, F. Abdalla, Shengzhou or sheng-zhou wu
- 1 April 2012
These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth
It is proposed that phosphorylation of autophagy receptors might be a general mechanism for regulation of cargo-selectiveautophagy, resulting in increased intracellular bacterial proliferation.
A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation
- I. Dikič, G. Tokiwa, S. Lev, S. Courtneidge, J. Schlessinger
- Biology, ChemistryNature
- 10 October 1996
It is proposed that Pyk2 acts with Src to link Gi- and Gq-coupled receptors with Grb2 and Sos to activate the MAP kinase signalling pathway in PC12 cells.
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.
- V. Kirkin, T. Lamark, T. Johansen
- BiologyMolecules and Cells
- 27 February 2009
Mechanism and medical implications of mammalian autophagy
It is now apparent that autophagy is deregulated in the context of various human pathologies, including cancer and neurodegeneration, and its modulation has considerable potential as a therapeutic approach.
Ubiquitin-Binding Domains in Y-Family Polymerases Regulate Translesion Synthesis
- Marzena Bienko, C. Green, I. Dikič
- 16 December 2005
The identification of two ubiquitin (Ub)–binding domains (UBM and UBZ), which are evolutionarily conserved in all Y-family TLS polymerases (pols), indicate that Ub-binding domains of Y- family polymerases play crucial regulatory roles in TLS.
A role for ubiquitin in selective autophagy.
- V. Kirkin, David G. McEwan, I. Novak, I. Dikič
- Biology, ChemistryMolecules and Cells
- 15 May 2009
Nix is a selective autophagy receptor for mitochondrial clearance
Nix functions as an autophagy receptor, which mediates mitochondrial clearance after mitochondrial damage and during erythrocyte differentiation, and ablation of the Nix:LC3/GABARAP interaction retards mitochondrial clearance in maturing murine reticulocytes.
Cargo recognition and trafficking in selective autophagy
- Alexandra Stolz, A. Ernst, I. Dikič
- Biology, ChemistryNature Cell Biology
- 30 May 2014
The current view on how cargo selection and transport are achieved during selective autophagy is discussed, and molecular mechanisms that are congruent between autophagosomal membranes and vesicle trafficking pathways are pointed out.
Regulation of endoplasmic reticulum turnover by selective autophagy
- Aliaksandr Khaminets, Theresa Heinrich, I. Dikič
- 3 June 2015
Severe disruption of Fam134b in mice causes expansion of the ER, inhibits ER turnover, sensitizes cells to stress-induced apoptotic cell death and leads to degeneration of sensory neurons, so selective ER-phagy via FAM134 proteins is indispensable for mammalian cell homeostasis and controls ER morphology and turnover in mice and humans.