PNOC wt Allele

Known as: N/OFQ, PPNOC, OFQ

Human PNOC wild-type allele is located in the vicinity of 8p21 and is approximately 26 kb in length. This allele, which encodes prepronociceptin…

National Institutes of Health

Papers overview

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2011

To examine if the biological activity of the N/OFQ peptide, which is the native ligand of the pain-related and viable drug target…

2008

Nociceptin/orphanin FQ (N/OFQ) is the endogenous ligand for the N/OFQ peptide receptor (NOP). Binding studies have relied on…

2007

Orphanin FQ (OFQ), an endogenous peptide ligand of opioid receptor-like receptors (ORLs), has properties similar to traditional…

2006

1 The peripheral effect of the ‘opioid‐like’ peptide nociceptin/orphanin FQ (N/OFQ) on joint blood flow was investigated in…

2005

Nociceptin (N/OFQ) exerts multiple effects in the gastrointestinal tract after central or peripheral administration. In the…

2003

Nociceptin/orphanin FQ (N/OFQ) is the endogenous ligand for the N/OFQ peptide receptor (NOP) and has been shown previously to…

2003

In this study we describe the activity of two cyclic nociceptin/orphanin FQ (N/OFQ) peptides; c[Cys10,14]N/OFQ(1–14)NH2 (c[Cys10…

2000

BACKGROUND & AIMS We have previously shown that orphanin FQ (OFQ) preferentially stimulates muscle contraction in the rat colon…

1999

Nociceptin/orphanin FQ (N/OFQ), an endogenous ligand for opioid receptor‐like receptor, has been shown to inhibit high‐voltage…

1998

Orphanin Fo (OFQ) is a newly-discovered neuropeptide which shares great simliar sequence with endogenous opioid peptide but with…