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PNOC wt Allele

Known as: N/OFQ, PPNOC, OFQ 
Human PNOC wild-type allele is located in the vicinity of 8p21 and is approximately 26 kb in length. This allele, which encodes prepronociceptin… 
National Institutes of Health

Related topics

Related topics

3 relations
8p21NociceptionSynaptic Transmission

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Roles of the bed nucleus of stria terminalis and of the amygdala in N/OFQ-mediated anxiety and HPA axis activation
Highly Cited
2006
Highly Cited
2006
Anxiolytic-like effects of nociceptin/orphanin FQ in the elevated plus maze and in the conditioned defensive burying test in rats
Highly Cited
2002
Highly Cited
2002
A combined pharmacological and genetic approach to investigate the role of orphanin FQ in learning and memory
Using a combination of the selective opioid receptor‐like1 (ORL1) receptor agonist, Ro 64‐6198, and orphanin FQ/nociceptin (OFQ/N… 
Highly Cited
2002
Highly Cited
2002
Orphanin FQ/nociceptin but not Ro 65-6570 inhibits the expression of cocaine-induced conditioned place preference
The present study investigated the effect of orphanin FQ/nociceptin (OFQ/N), the endogenous ligand of the opioid receptor-like 1… 
Review
2002
Review
2002
The orphanin FQ/nociceptin knockout mouse: A behavioral model for stress responses
Transgenic mice lacking expression of the OFQ/N precursor protein have provided exciting insights in the physiological functions… 
Highly Cited
2002
Highly Cited
2002
Inflammatory mediators increase the expression of nociceptin/orphanin FQ in rat astrocytes in culture
In the central nervous system, glial cells play an important role in inflammatory and immune responses, and opioid peptides have… 
Highly Cited
2001
Highly Cited
2001
Nociceptin inhibits calcium channel currents in a subpopulation of small nociceptive trigeminal ganglion neurons in mouse
1 The effects of nociceptin/orphanin FQ (N/OFQ) and opioid receptor agonists on voltage‐activated calcium channel currents (ICa… 
2001
2001
Orphanin FQ/nociceptin binds to functionally coupled ORL1 receptors on human immune cell lines and alters peripheral blood mononuclear cell proliferation
Highly Cited
2000
Highly Cited
2000
Opioids affect acquisition of LiCl-induced conditioned taste aversion: involvement of OT and VP systems.
Aversive properties of lithium chloride (LiCl) are mediated via pathways comprising neurons of the nucleus of the solitary tract… 
Highly Cited
1999
Highly Cited
1999
Functional significance of a newly discovered neuropeptide, orphanin FQ, in rat gastrointestinal motility.
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