Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor
- R. Reinscheid, H. Nothacker, O. Civelli
- Biology, ChemistryScience
- 3 November 1995
Orphanin FQ may act as a transmitter in the brain by modulating nociceptive and locomotor behavior by binding to its receptor in a saturable manner and with high affinity.
Neuropeptide S A Neuropeptide Promoting Arousal and Anxiolytic-like Effects
- Yanling Xu, R. Reinscheid, O. Civelli
- Biology, PsychologyNeuron
- 19 August 2004
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine
- H. V. Tol, J. Bunzow, O. Civelli
- Psychology, BiologyNature
- 18 April 1991
The cloning of a gene that encodes a dopamine receptor gene that has high homology to the human dopamine D2 and D3 receptor genes is reported, which suggests the existence of other types of dopamine receptors which are more sensitive to clozapine.
Distribution of neuropeptide S receptor mRNA and neurochemical characteristics of neuropeptide Sâexpressing neurons in the rat brain
- Yanling Xu, C. Gall, Valerie R. Jackson, O. Civelli, R. Reinscheid
- BiologyThe Journal of comparative neurology
- 2007
Data suggest that the NPS system may play a key role in modulating a variety of physiological functions, especially arousal, anxiety, learning and memory, and energy balance, as well as regulate energy homeostasis.
Molecular diversity of the dopamine receptors.
- O. Civelli, J. Bunzow, D. Grandy
- Psychology, BiologyAnnual Review of Pharmacology and Toxicology
- 1993
The search for the ideal drug(s) that will treat one disorder without affecting the other has led to the design of several dopamine r ceptor ligands that, in turn, have increased the understanding of the dopaminergic system.
Molecular characterization of the melanin-concentrating-hormone receptor
- Yumiko Saito, H. Nothacker, Zhiwei Wang, Steven H. S. Lin, F. Leslie, O. Civelli
- BiologyNature
- 15 July 1999
It is shown that the natural ligand of this receptor is the neuropeptide melanin-concentrating hormone (MCH), a cyclic peptide that regulates a variety of functions in the mammalian brain, in particular feeding behaviour, and it is demonstrated that nanomolar concentrations of MCH strongly activate SLC-1-related pathways through GÎąi and/or GÎąq proteins.
Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor.
- Q. Zhou, C. Li, M. Olah, R. A. Johnson, G. Stiles, O. Civelli
- Biology, ChemistryProceedings of the National Academy of SciencesâŚ
- 15 August 1992
The highest expression of R226 was in the testis and low-level mRNAs were also found in the lung, kidneys, heart, and some parts of the central nervous system such as cortex, striatum, and olfactory bulb, suggesting a possible role for adenosine in reproduction.
Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress.
- F. Jenck, J. Moreau, O. Civelli
- Biology, PsychologyProceedings of the National Academy of SciencesâŚ
- 23 December 1997
It is shown that OFQ plays an important role in higher brain functions because it can act as an anxiolytic to attenuate the behavioral inhibition of animals acutely exposed to stressful/anxiogenic environmental conditions.
Multiple dopamine D4 receptor variants in the human population
- H. V. Tol, Caren M. Wu, V. Jovanovic
- Biology, PsychologyNature
- 9 July 1992
This is the first report of a receptor in the catecholamine receptor family that displays polymorphic variation in the human population and such variation among humans may underlie individual differences in susceptibility to neuropsychiatric disease and in responsiveness to antipsychotic medication.
Expression of the melaninâconcentrating hormone (MCH) receptor mRNA in the rat brain
- Yumiko Saito, Michelle Cheng, F. Leslie, O. Civelli
- BiologyThe Journal of comparative neurology
- 18 June 2001
High levels of expression of MCHR mRNA are found in most anatomical areas implicated in control of olfaction, with the exception of the main olfactory bulb, which suggests that MCH may act at various levels of the brain to integrate various aspects of feeding behavior.
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