O. Civelli

Publications254
h-index67
Citations22,192
Highly Influential Citations789
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Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor
TLDR
Orphanin FQ may act as a transmitter in the brain by modulating nociceptive and locomotor behavior by binding to its receptor in a saturable manner and with high affinity. Expand
Neuropeptide S A Neuropeptide Promoting Arousal and Anxiolytic-like Effects
TLDR
It is reported that a neuropeptide, NPS, potently modulates wakefulness and could also regulate anxiety, and it is shown that the LC region encompasses distinct nuclei expressing different arousal-promoting neurotransmitters. Expand
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine
TLDR
The cloning of a gene that encodes a dopamine receptor gene that has high homology to the human dopamine D2 and D3 receptor genes is reported, which suggests the existence of other types of dopamine receptors which are more sensitive to clozapine. Expand
Distribution of neuropeptide S receptor mRNA and neurochemical characteristics of neuropeptide S‐expressing neurons in the rat brain
TLDR
Data suggest that the NPS system may play a key role in modulating a variety of physiological functions, especially arousal, anxiety, learning and memory, and energy balance, as well as regulate energy homeostasis. Expand
Molecular diversity of the dopamine receptors.
TLDR
The search for the ideal drug(s) that will treat one disorder without affecting the other has led to the design of several dopamine r ceptor ligands that, in turn, have increased the understanding of the dopaminergic system. Expand
Molecular characterization of the melanin-concentrating-hormone receptor
TLDR
It is shown that the natural ligand of this receptor is the neuropeptide melanin-concentrating hormone (MCH), a cyclic peptide that regulates a variety of functions in the mammalian brain, in particular feeding behaviour, and it is demonstrated that nanomolar concentrations of MCH strongly activate SLC-1-related pathways through Gαi and/or Gαq proteins. Expand
Expression of the melanin‐concentrating hormone (MCH) receptor mRNA in the rat brain
TLDR
High levels of expression of MCHR mRNA are found in most anatomical areas implicated in control of olfaction, with the exception of the main olfactory bulb, which suggests that MCH may act at various levels of the brain to integrate various aspects of feeding behavior. Expand
Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor.
TLDR
The highest expression of R226 was in the testis and low-level mRNAs were also found in the lung, kidneys, heart, and some parts of the central nervous system such as cortex, striatum, and olfactory bulb, suggesting a possible role for adenosine in reproduction. Expand
Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress.
TLDR
It is shown that OFQ plays an important role in higher brain functions because it can act as an anxiolytic to attenuate the behavioral inhibition of animals acutely exposed to stressful/anxiogenic environmental conditions. Expand
Pharmacological Characterization of Human and Murine Neuropeptide S Receptor Variants
TLDR
The N107I polymorphism in the human NPS receptor results in a gain-of-function characterized by an increase in agonist potency without changing binding affinity in NPSR Ile107, implying a mechanism of enhanced NPS signaling that might have physiological significance for brain function as well as peripheral tissues that express NPS receptors. Expand
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