• Publications
  • Influence
Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models
Alzheimer's disease (AD) is characterized by amyloid-beta (Abeta) and tau deposition in brain. It has emerged that Abeta toxicity is tau dependent, although mechanistically this link remains unclear.Expand
  • 1,266
  • 75
Cellular and synaptic adaptations mediating opioid dependence.
Although opioids are highly effective for the treatment of pain, they are also known to be intensely addictive. There has been a massive research investment in the development of opioid analgesics,Expand
  • 797
  • 61
  • PDF
Regulation of µ-Opioid Receptors: Desensitization, Phosphorylation, Internalization, and Tolerance
Morphine and related µ-opioid receptor (MOR) agonists remain among the most effective drugs known for acute relief of severe pain. A major problem in treating painful conditions is that toleranceExpand
  • 453
  • 33
  • PDF
How opioids inhibit GABA-mediated neurotransmission
The midbrain region periaqueductal grey (PAG) is rich in opioid receptors and endogenous opioids and is a major target of analgesic action in the central nervous system. It has been proposed that theExpand
  • 434
  • 27
Distinct cellular properties of identified dopaminergic and GABAergic neurons in the mouse ventral tegmental area
Non‐technical summary The lower mid‐brain of rodent is home to addiction and hedonism of substances of abuse. Due to overlapping physiological properties among different types of nerve cell withinExpand
  • 98
  • 26
Cellular neuroadaptations to chronic opioids: tolerance, withdrawal and addiction
  • M. Christie
  • Psychology, Medicine
  • British journal of pharmacology
  • 1 May 2008
A large range of neuroadaptations develop in response to chronic opioid exposure and these are thought to be more or less critical for expression of the major features of opioid addiction: tolerance,Expand
  • 327
  • 25
Actions of cannabinoids on membrane properties and synaptic transmission in rat periaqueductal gray neurons in vitro.
The midbrain periaqueductal gray (PAG) is a major site of cannabinoid-mediated analgesia in the central nervous system. In the present study, we examined the actions of cannabinoids on rat PAGExpand
  • 216
  • 17
  • PDF
Cloning and expression of a rat D2 dopamine receptor cDNA
Dopamine receptors are classified into D1 and D2 subtypes on the basis of their pharmacological and biochemical characteristics1,2. The D2 dopamine receptor has been implicated in the pathophysiologyExpand
  • 1,047
  • 16
Presynaptic inhibitory action of opioids on synaptic transmission in the rat periaqueductal grey in vitro.
1. The actions of opioids on synaptic transmission in rat periaqueductal grey (PAG) neurones were examined using whole‐cell patch‐clamp recordings in brain slices. 2. Methionine enkephalin (ME; 10Expand
  • 217
  • 15
Opioid Agonists Have Different Efficacy Profiles for G Protein Activation, Rapid Desensitization, and Endocytosis of Mu-opioid Receptors*
The differential ability of various μ-opioid receptor (MOP) agonists to induce rapid receptor desensitization and endocytosis of MOP could arise simply from differences in their efficacy to activateExpand
  • 163
  • 13
  • PDF