A combined pharmacological and genetic approach to investigate the role of orphanin FQ in learning and memory

@article{Higgins2002ACP,
  title={A combined pharmacological and genetic approach to investigate the role of orphanin FQ in learning and memory},
  author={G. A. Higgins and JN Kew and J. Grayson Richards and Hiroshi Takeshima and François Jenck and Geo Adam and Juergen Wichmann and J. A. Kemp and A. J. Grottick},
  journal={European Journal of Neuroscience},
  year={2002},
  volume={15}
}
Using a combination of the selective opioid receptor‐like1 (ORL1) receptor agonist, Ro 64‐6198, and orphanin FQ/nociceptin (OFQ/N) peptide knockout (KO) mice, the influence of OFQ/N on cognition has been studied in the rodent. In wild type, C57BL/6J mice, Ro 64‐6198 (0.3–1 mg/kg i.p.) impaired the acquisition of spatial learning in the Morris water maze, although a mild neurological impairment was evident which complicated precise interpretation. In Lister hooded rats, Ro 64‐6198 (6 mg/kg i.p… 

Nociceptin and the NOP receptor in aversive learning in mice

Effects of nociceptin/orphanin FQ in the acquisition of contextual and tone fear conditioning in rats.

The data support the negative role of N/OFQ in the acquisition of aversively motivated tasks, which encompass a spatial component and depend on the hippocampus.

Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species

The findings of this study confirm the potent, ORL-1 receptor-mediated, anxiolytic-like effects of Ro64-6198, extending the findings across three species.

KNOCKOUT OF THE NOCICEPTIN / ORPHANIN FQ ECEPTOR IN THE RAT DOES NOT INDUCE COMPENSATORY

A novel mutant rat lacking OPr without compensatory changes in , and opioid eceptors is presented and it is anticipated that this mutant rat will have heurisic value to further understand the function of NOPr.

The Nociceptin/Orphanin FQ System and the Regulation of Memory.

The consequences of the pharmacological manipulation of the N/OFQ system by NOP receptor ligands on learning processes and on the consolidation of various types of long-term memory are described.

Distinct effects of nociceptin analogs on scopolamine-induced memory impairment in mice.

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