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Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene
TLDR
Investigation of the behavioural effects of morphine reveals that a lack of μ receptors abolishes the analgesic effect of morphine, as well as place-preference activity and physical dependence, and concludes that the µ-opioid-receptor gene product is a mandatory component of the opioid system for morphine action.
Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses.
TLDR
The Oprd1-encoded receptor, which has been proposed to be a promising target for the clinical management of pain, should also be considered in the treatment of drug addiction and other mood-related disorders.
Motivational Effects of Cannabinoids Are Mediated by μ-Opioid and κ-Opioid Receptors
Repeated THC administration produces motivational and somatic adaptive changes leading to dependence in rodents. To investigate the molecular basis for cannabinoid dependence and its possible
kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system.
TLDR
The expression of kappa-opioid receptor mRNA in human brain, as estimated by reverse transcription-polymerase chain reaction, is consistent with the involvement of k Kappa-opIOid receptors in pain perception, neuroendocrine physiology, affective behavior, and cognition.
Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors.
TLDR
An opposing activity of mu- and kappa-opioid receptors in modulating reward pathways forms the basis for the dual euphoric-dysphoric activity of THC.
Distribution of nociceptin/orphanin FQ receptor transcript in human central nervous system and immune cells
TLDR
Results show comparable expression levels of the hORL-1 gene in both nervous and immune systems, suggesting that the ORL- 1-encoded receptor may participate to neuronal and non-neuronal physiological functions in humans.
Mice deficient for δ- and μ-opioid receptors exhibit opposing alterations of emotional responses
TLDR
The Oprd1-encoded receptor, which has been proposed to be a promising target for the clinical management of pain, should also be considered in the treatment of drug addiction and other mood-related disorders.
Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization.
TLDR
The 5-HT5A gene colocalized with the mouse mutation reeler and the human mutation holoprosencephaly type 3, which both result in abnormal brain development, raising the possibility that the 5- HT5A receptor plays a role in brain development.
Quantitative autoradiographic mapping of mu-, delta- and kappa-opioid receptors in knockout mice lacking the mu-opioid receptor gene.
Mice lacking the mu-opioid receptor (MOR) gene have been successfully developed by homologous recombination and these animals show complete loss of analgesic responses to morphine as well as loss of
Naloxone fails to produce conditioned place aversion in μ-opioid receptor knock-out mice
TLDR
The notion that naloxone produces aversion by antagonizing tonic opioid activity at the mu-opioid receptor is supported by data that further support the notion that this effect is centrally mediated.
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