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PARK2 wt Allele

Known as: Parkinson Disease (Autosomal Recessive, Juvenile) 2, Parkin wt Allele, PDJ, AR-JP 
Human PARK2 wild-type allele is located within 6q25.2-q27 and is approximately 1459 kb in length. This allele, which encodes E3 ubiquitin-protein… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Mutations in the parkin gene are expected to play an essential role in autosomal recessive Parkinson's disease. Recent studies… Expand
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Highly Cited
2010
Highly Cited
2010
OBJECTIVE To assess the frequency and clinical characteristics of carriers of previously identified mutations in 6 genes… Expand
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Highly Cited
2003
Highly Cited
2003
Background: The vast majority of the parkin mutations previously identified have been found in individuals with juvenile or early… Expand
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2003
2003
OBJECTIVES To report clinical, pathological and genetic findings in a Tunisian kindred with autosomal recessive juvenile… Expand
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Highly Cited
2003
Highly Cited
2003
Parkinson disease (PD) is the second most common neurodegenerative disorder. We studied 754 affected individuals, comprising 425… Expand
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2002
2002
Loss-of-function mutations in the parkin gene were first identified in autosomal recessive juvenile parkinsonism (AR-JP… Expand
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Highly Cited
2001
Highly Cited
2001
A Dutch family with autosomal recessive early-onset parkinsonism showed a heterozygous missense mutation in combination with a… Expand
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Highly Cited
2001
Highly Cited
2001
A wide variety of mutations in the parkin gene, including exon deletions and duplications, as well as point mutations, result in… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Mutations in the parkin gene have recently been identified in patients with early-onset Parkinson's disease, but the… Expand
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Highly Cited
2000
Highly Cited
2000
We report the neuropathologic and genetic features of a 70-year-old man with autosomal-recessive juvenile parkinsonism (AR-JP… Expand
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