The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease
A key role for NMS in the clinical frame of PD is supported and the need to address them specifically in clinical trials using dedicated scales is addressed.
Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria
Clinical diagnostic criteria, published in 1996 by the National Institute of Neurological Disorders and Stroke/Society for PSP have excellent specificity, but their sensitivity is limited for variant PSP syndromes with presentations other than Richardson's syndrome.
Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Parkinson's disease: a randomised, controlled, double-blind, double-dummy study
Patterns of regional brain activation associated with different forms of motor learning
Valvular heart disease and the use of dopamine agonists for Parkinson's disease.
- R. Zanettini, A. Antonini, G. Gatto, R. Gentile, S. Tesei, G. Pezzoli
- MedicineNew England Journal of Medicine
- 4 January 2007
The frequency of clinically important valve regurgitation was significantly increased in Patients taking pergolide or cabergoline, but not in patients taking non-ergot-derived dopamine agonists, as compared with control subjects.
Metabolic hyperfrontality and psychopathology in the ketamine model of psychosis using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG)
Parkinson's disease: the non-motor issues.
MR imaging of the superior profile of the midbrain: differential diagnosis between progressive supranuclear palsy and Parkinson disease.
- A. Righini, A. Antonini, G. Pezzoli
- Medicine, BiologyAJNR. American journal of neuroradiology
- 1 June 2004
An abnormal superior profile of the midbrain facilitates the distinction of PSP from PD and may support the clinical differential diagnosis of parkinsonism.
Functional brain networks in DYT1 dystonia
The findings indicate the penetrance of the DYT1 gene is considerably greater than previously assumed, and ITD is mediated through the interaction of functional brain networks relating separately to gene status and to abnormal movement.
Effect of age on D2 dopamine receptors in normal human brain measured by positron emission tomography and 11C-raclopride.
- A. Antonini, K. Leenders, H. Reist, R. Thomann, H. Beer, J. Locher
- BiologyArchives of Neurology
- 1 May 1993
The results suggest that D2 dopamine receptor binding sites (mainly postsynaptically located) decrease as a consequence of normal aging in parallel with the decline of the presynaptic nigrostriatal dopaminergic neuronal system.