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Memory-specific temporal profiles of gene expression in the hippocampus
TLDR
Results of this study suggest that while learning and physical activity involve common groups of genes, the behavior of learning and memory emerges from unique patterns of gene expression across time. Expand
The impact of physical activity on psychological health during Covid-19 pandemic in Italy
TLDR
Looking at changes in the physical activity levels during self-quarantine in Italy, and the impact of exercise on psychological health, suggests maintaining a regular exercise routine is a key strategy for physical and mental health during a forced rest period like the current coronavirus emergency. Expand
Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia
TLDR
Increasing evidence indicates that factors such as oxidative stress and disturbed protein metabolism and their interaction in a vicious cycle are central to FRDA pathogenesis, and manipulation of endogenous cellular defense mechanisms, such as the heat shock response, may represent an innovative approach to therapeutic intervention in diseases causing tissue damage. Expand
Curcumin activates defensive genes and protects neurons against oxidative stress.
TLDR
This study gives additional support to the possible use of curcumin as a dietary preventive agent against oxidative stress-related diseases. Expand
Gene expression profiles of heme oxygenase isoforms in the rat brain
TLDR
To discriminate the regional and cellular distribution of HO isoforms in the CNS, a real time quantitative reverse transcription-polymerase chain reaction (RT-PCR) protocol is developed and for the first time the expression of all known HO isoform mRNAs in different rat brain areas is assessed. Expand
The Major Green Tea Polyphenol, (-)-Epigallocatechin-3-Gallate, Induces Heme Oxygenase in Rat Neurons and Acts as an Effective Neuroprotective Agent against Oxidative Stress
TLDR
It is demonstrated that EGCG, the major green tea catechin, induced HO-1 expression in cultured neurons, possibly by activation of the transcription factor Nrf2, and by this mechanism was able to protect against oxidative stress–induced cell death. Expand
Potential role of probiotics on colorectal cancer prevention
TLDR
Several mechanisms could explain the preventive action of probiotics against colorectal cancer onset: alteration of the intestinal microflora; inactivation of cancerogenic compounds; competition with putrefactive and pathogenic microbiota; improvement of the host’s immune response; and inhibition of tyrosine kinase signaling pathways. Expand
Pituitary adenylate cyclase activating polypeptide prevents apoptosis in cultured cerebellar granule neurons.
TLDR
The activation of type I PACAP receptors may contribute to the survival of cerebellar granule neurons by reducing the development of apoptosis in a dose-dependent manner. Expand
Dopamine D3 Receptor Is Necessary for Ethanol Consumption: An Approach with Buspirone
TLDR
DA signaling via D3R is essential for ethanol-related reward and consumption and may represent a novel therapeutic target for weaning and evaluated buspirone, an approved drug for anxiety disorders endowed with D3 R antagonist activity, that resulted effective in inhibiting ethanol intake. Expand
Differentiation induces pituitary adenylate cyclase-activating polypeptide receptor expression in PC-12 cells.
TLDR
The increased PACAP responsiveness induced by these growth factors in PC-12 cells may therefore result from the expression of the PACAP-R-hop isoform, positively coupled to both adenylyl cyclase and phospholipase C. Expand
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