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PARK2 gene

Known as: AR-JP, Parkinson Disease (Autosomal Recessive, Juvenile) 2, Parkin Gene, PRKN 
This gene may play a role in the mediation of proteasomal targeting.
National Institutes of Health

Related topics

Related topics

9 relations
Cell DeathPARK2 protein, humanPARK3 genePARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE

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PARK2 wt Allele

Papers overview

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Highly Cited
2010
Highly Cited
2010
PINK1/Parkin direct mitochondria to autophagy
Mutations in PTEN-induced putative kinase 1 (PINK1) and PARK2/Parkin cause autosomal recessive forms of Parkinson disease. In… 
Highly Cited
2006
Highly Cited
2006
An Efficient Method for the Derivation of Mouse Embryonic Stem Cells
Mouse embryonic stem cells (mESCs) represent a unique tool for many researchers; however, the process of ESC derivation is often… 
2005
2005
Effect of overexpression of wild‐type or mutant parkin on the cellular response induced by toxic insults
Mutations in parkin are involved in some cases of autosomal recessive juvenile parkinsonism (AR‐JP), but it is not known how they… 
2005
2005
Early-onset Parkinson's disease in a Chinese population: 99mTc-TRODAT-1 SPECT, Parkin gene analysis and clinical study.
Highly Cited
2004
Highly Cited
2004
PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations
The authors performed linkage analysis in 39 families with autosomal recessive early-onset PD (AR-EOPD) negative for parkin and… 
2003
2003
Frequency of parkin mutations in late‐onset Parkinson's disease
Highly Cited
2002
Highly Cited
2002
Functional association of the parkin gene promoter with idiopathic Parkinson's disease.
Loss-of-function mutations in the parkin gene were first identified in autosomal recessive juvenile parkinsonism (AR-JP… 
Highly Cited
2002
Highly Cited
2002
The striatal dopaminergic deficit is dependent on the number of mutant alleles in a family with mutations in the parkin gene: evidence for enzymatic parkin function in humans
Highly Cited
2002
Highly Cited
2002
Linkage stratification and mutation analysis at the parkin locus identifies mutation positive Parkinson's disease families
Parkinson's disease (PD) is one of the most common neurological disorders in humans with an overall prevalence of 1:1000 with the… 
Review
2001
Review
2001
The aetiology of idiopathic Parkinson's disease
Agents potentially involved in the aetiology of idiopathic Parkinson's disease are discussed. These include factors regulating… 
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