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PARK2 gene

Known as: AR-JP, Parkinson Disease (Autosomal Recessive, Juvenile) 2, Parkin Gene, PRKN 
This gene may play a role in the mediation of proteasomal targeting.
National Institutes of Health

Related topics

Related topics

9 relations
Cell DeathPARK2 protein, humanPARK3 genePARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE

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PARK2 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Isolated and combined dystonia syndromes – an update on new genes and their phenotypes
Recent consensus on the definition, phenomenology and classification of dystonia centres around phenomenology and guides our… 
Review
2011
Review
2011
Autophagic pathways in Parkinson disease and related disorders
Macroautophagy and chaperone-mediated autophagy (CMA) are the two main mammalian lysosomal proteolytic systems. In macroautophagy… 
Review
2008
Review
2008
Emerging roles of S-nitrosylation in protein misfolding and neurodegenerative diseases.
Overactivation of N-methyl-D-aspartate (NMDA)-type glutamate receptors accounts, at least in part, for excitotoxic neuronal… 
Highly Cited
2006
Highly Cited
2006
An Efficient Method for the Derivation of Mouse Embryonic Stem Cells
Mouse embryonic stem cells (mESCs) represent a unique tool for many researchers; however, the process of ESC derivation is often… 
Highly Cited
2005
Highly Cited
2005
Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function.
Mutations in parkin are currently recognized as the most common cause of familial Parkinsonism. Emerging evidence also suggests… 
Highly Cited
2004
Highly Cited
2004
Striatal and cortical pre- and postsynaptic dopaminergic dysfunction in sporadic parkin-linked parkinsonism.
To investigate striatal and cortical pre- and postsynaptic dopaminergic function in parkin-linked parkinsonism, 13 unrelated… 
Highly Cited
2003
Highly Cited
2003
A Product of the Human Gene Adjacent to parkin Is a Component of Lewy Bodies and Suppresses Pael Receptor-induced Cell Death*
Parkin, a RING-type ubiquitin ligase, is the product of the gene responsible for autosomal recessive juvenile parkinsonism. A… 
Review
2002
Review
2002
MPTP: insights into parkinsonian neurodegeneration.
Highly Cited
2002
Highly Cited
2002
Park6‐linked parkinsonism occurs in several european families
The Parkin gene on 6q25.2–27 is responsible for about 50% of autosomal recessive juvenile parkinsonism and less than 20% of… 
Highly Cited
2002
Highly Cited
2002
Functional association of the parkin gene promoter with idiopathic Parkinson's disease.
Loss-of-function mutations in the parkin gene were first identified in autosomal recessive juvenile parkinsonism (AR-JP… 
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