PARK2 protein, human

Known as: Parkinson disease (autosomal recessive, juvenile) 2, parkin, human, E3 Ubiquitin-Protein Ligase Parkin, Parkinson Disease Protein 2 
E3 ubiquitin-protein ligase parkin (465 aa, ~52 kDa) is encoded by the human PARK2 gene. This protein may play a role in the ubiquitination of… (More)
National Institutes of Health

Papers overview

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Review
2014
Review
2014
Parkinson's disease (PD) is a degenerative disease of the central nervous system, of which patomechanizm entirely is not clear… (More)
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Highly Cited
2011
Highly Cited
2011
Recent studies delineate a pathway involving familial Parkinson's disease (PD)-related proteins PINK1 and Parkin, in which PINK1… (More)
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Highly Cited
2011
Highly Cited
2011
Mutations in Parkin, an E3 ubiquitin ligase that regulates protein turnover, represent one of the major causes of familial… (More)
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Highly Cited
2010
Highly Cited
2010
Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) and PARK2/Parkin mutations cause autosomal recessive… (More)
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Highly Cited
2010
Highly Cited
2010
Loss-of-function mutations in the PINK1 or parkin genes result in recessive heritable forms of parkinsonism. Genetic studies of… (More)
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Highly Cited
2010
Highly Cited
2010
Mitochondrial dysfunction is an early sign of many neurodegenerative diseases. Very recently, two Parkinson disease (PD… (More)
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Highly Cited
2008
Highly Cited
2008
Loss-of-function mutations in Park2, the gene coding for the ubiquitin ligase Parkin, are a significant cause of early onset… (More)
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Highly Cited
2001
Highly Cited
2001
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons… (More)
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Highly Cited
2000
Highly Cited
2000
Parkinson's disease is a common neurodegenerative disorder in which familial-linked genes have provided novel insights into the… (More)
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Highly Cited
1999
Highly Cited
1999
Autosomal recessive juvenile parkinsonism (AR-JP) is a distinct clinical entity characterized by a selective degeneration of… (More)
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