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Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants.
Cannabidiol was more protective against glutamate neurotoxicity than either ascorbate or alpha-tocopherol, indicating it to be a potent antioxidant, and data suggest that the naturally occurring, nonpsychotropic cannabinoid, cannABidiol, may be a potentially useful therapeutic agent for the treatment of oxidative neurological disorders such as cerebral ischemia. Expand
Transient Receptor Potential Channel Activation Causes a Novel Form of [Ca 2+]i Oscillations and Is Not Involved in Capacitative Ca 2+ Entry in Glial Cells
In glial cells, natively expressed TRPC3s mediates a novel form of Ca 2- signaling, distinct from capacitative Ca 2+ entry, which suggests a specific signaling function for this channel inglial cells. Expand
Functional and molecular diversity of PACAP/VIP receptors in cortical neurons and type I astrocytes
In the present study we determined the mRNA‐expression of pituitary adenylate cyclase activating polypeptide (PACAP)/vasoactive intestinal peptide (VIP) receptors in primary cultures of rat corticalExpand
Neuroprotective Antioxidants from Marijuana a
Preliminary studies in a rat model of focal cerebral ischemia suggest that cannabidiol may be at least as effective in vivo as seen in these in vitro studies, and cannabinoids can act as an antioxidants in neuronal cultures. Expand
Stressed to death: targeting endoplasmic reticulum stress response induced apoptosis in gliomas.
The possibility that the endoplasmic reticulum stress response (ERSR) could be a possible target to develop chemotherapeutic agents to induce toxicity in glioma cells is explored. Expand
The Hop Cassette of the PAC1 Receptor Confers Coupling to Ca2+ Elevation Required for Pituitary Adenylate Cyclase-activating Polypeptide-evoked Neurosecretion*
Exercise of PACAP receptors in neuroendocrine rather than nonneuroendocrine cells reveals key differences between PAC1hop and PAC1null coupling, indicating an important and previously unrecognized role of the hop cassette in PAC1-mediated Ca2+ signaling in neuro endocrine cells. Expand
Coincident Elevation of cAMP and Calcium Influx by PACAP-27 Synergistically Regulates Vasoactive Intestinal Polypeptide Gene Transcription through a Novel PKA-Independent Signaling Pathway
It is shown that PACAP-27-induced calcium influx through voltage-sensitive calcium channels (VSCCs), together with elevation of intracellular cAMP, was sufficient to stimulate vasoactive intestinal polypeptide (VIP) biosynthesis at least 40-fold. Expand
Cannabinoid receptor activation and elevated cyclic AMP reduce glutamate neurotoxicity
Cannabinoids protect against ischemic injury in vivo, but only reduce toxicity in vitro when cAMP levels are elevated, possibly suggesting that cAMP elevation during reperfusion reduces brain injury by off‐setting the effect of Gi/o protein‐coupled systems on adenylate cyclase. Expand
Mitochondria regulate Ca2+ wave initiation and inositol trisphosphate signal transduction in oligodendrocyte progenitors
It is found that AA increased cytosolic Ca2+, markedly reduced agonist‐evoked inositol trisphosphate (IP3) production, and also enhanced phosphatidylinositol 4,5‐bisph phosphate (PIP2) binding to the Ca2+ dependent protein gelsolin, which may explain the reduction in puff probability and wave speed after AA treatment. Expand