Polyubiquitination

The type of ubiquitin modification determines the functional consequences for the modified protein. Polyubiquitination, which involves chains of… (More)
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
Cell-surface death receptors such as DR4 and DR5 trigger apoptosis through a death-inducing signaling complex (DISC) that… (More)
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Highly Cited
2008
Highly Cited
2008
Nod1 and Nod2 are intracellular proteins that are involved in host recognition of specific bacterial molecules and are… (More)
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Highly Cited
2008
Highly Cited
2008
Chronic stalling of DNA replication forks caused by DNA damage can lead to genomic instability. Cells have evolved lesion bypass… (More)
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Highly Cited
2007
Highly Cited
2007
Sequestration of misfolded proteins into pericentriolar inclusions called aggresomes is a means that cells use to minimize… (More)
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Highly Cited
2007
Highly Cited
2007
The Rip2 kinase contains a caspase recruitment domain and has been implicated in the activation of the transcriptional factor NF… (More)
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Highly Cited
2005
Highly Cited
2005
Nerve growth factor (NGF) binding to p75(NTR) influences TrkA signaling, yet the molecular mechanism is unknown. We observe that… (More)
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Highly Cited
2003
Highly Cited
2003
Although Mdm2-mediated ubiquitination is essential for both degradation and nuclear export of p53, the molecular basis for the… (More)
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Highly Cited
2003
Highly Cited
2003
Rapid turnover of the tumor suppressor protein p53 requires the MDM2 ubiquitin ligase, and both interact with p300-CREB-binding… (More)
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Highly Cited
2001
Highly Cited
2001
Gap1p, the general amino acid permease of Saccharomyces cerevisiae, is regulated by intracellular sorting decisions that occur in… (More)
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Highly Cited
1996
Highly Cited
1996
Treatment of SKBr3 human breast carcinoma cells with the benzoquinoid ansamycin, geldanamycin, rapidly depletes p185c-erbB-2… (More)
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