Skip to search formSkip to main contentSkip to account menu

DDB2 protein, human

Known as: DDBb, DNA Damage-Binding Protein 2, XPE48 protein, human 
DNA damage-binding protein 2 (427 aa, ~48 kDa) is encoded by the human DDB2 gene. This protein plays a role in the mediation of DNA repair.
National Institutes of Health

Related topics

Related topics

12 relations
DDB2 geneDNA RepairDNA Repair GeneDNA repair protein

Broader (2)

DDB2 wt AlleleDNA-Binding Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity
DNA damage recognition subunits such as DDB2 and XPC protect the human skin from ultraviolet (UV) light-induced genome… 
Highly Cited
2012
Highly Cited
2012
PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1
PARP1-mediated poly(ADP-ribosyl)ation of DDB2 prolongs its occupation on UV-damaged chromatin and promotes the recruitment of the… 
Highly Cited
2012
Highly Cited
2012
DDB2 promotes chromatin decondensation at UV-induced DNA damage
In addition to its role in DNA lesion recognition, the damaged DNA-binding protein DDB2 elicits unfolding of large-scale… 
Highly Cited
2011
Highly Cited
2011
The Molecular Basis of CRL4DDB2/CSA Ubiquitin Ligase Architecture, Targeting, and Activation
Highly Cited
2006
Highly Cited
2006
The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.
Xeroderma pigmentosum (XP) is a heritable human disorder characterized by defects in nucleotide excision repair (NER) and the… 
Highly Cited
2006
Highly Cited
2006
Cullin 4A-mediated Proteolysis of DDB2 Protein at DNA Damage Sites Regulates in Vivo Lesion Recognition by XPC*
Xeroderma pigmentosum (XP) complementation group E gene product, damaged DNA-binding protein 2 (DDB2), is a subunit of the DDB… 
Highly Cited
2006
Highly Cited
2006
DNA damage binding protein component DDB1 participates in nucleotide excision repair through DDB2 DNA-binding and cullin 4A ubiquitin ligase activity.
Functional defect in DNA damage binding (DDB) activity has a direct relationship to decreased nucleotide excision repair (NER… 
Highly Cited
2005
Highly Cited
2005
DDB1-DDB2 (Xeroderma Pigmentosum Group E) Protein Complex Recognizes a Cyclobutane Pyrimidine Dimer, Mismatches, Apurinic/Apyrimidinic Sites, and Compound Lesions in DNA*
The DDB protein complex, comprising the subunits DDB1 and DDB2, binds tightly to UV light-irradiated DNA. Mutations in DDB2 are… 
Highly Cited
2004
Highly Cited
2004
UV radiation-induced XPC translocation within chromatin is mediated by damaged-DNA binding protein, DDB2.
The tumor suppressor p53 protein has been established as an important factor in modulating the efficiency of global genomic… 
Highly Cited
2003
Highly Cited
2003
True XP group E patients have a defective UV-damaged DNA binding protein complex and mutations in DDB2 which reveal the functional domains of its p48 product.
Xeroderma pigmentosum (XP) is a skin cancer-prone autosomal recessive disease characterized by inability to repair UV-induced DNA… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)