DDB2 promotes chromatin decondensation at UV-induced DNA damage

@inproceedings{Luijsterburg2012DDB2PC,
  title={DDB2 promotes chromatin decondensation at UV-induced DNA damage},
  author={Martijn S. Luijsterburg and Michael Lindh and Kl{\`a}ra {\'A}cs and Mischa G. Vrouwe and Alex Pines and Haico van Attikum and L. H. Mullenders and Nico P Dantuma},
  booktitle={The Journal of cell biology},
  year={2012}
}
Nucleotide excision repair (NER) is the principal pathway that removes helix-distorting deoxyribonucleic acid (DNA) damage from the mammalian genome. Recognition of DNA lesions by xeroderma pigmentosum group C (XPC) protein in chromatin is stimulated by the damaged DNA-binding protein 2 (DDB2), which is part of a CUL4A-RING ubiquitin ligase (CRL4) complex. In this paper, we report a new function of DDB2 in modulating chromatin structure at DNA lesions. We show that DDB2 elicits unfolding of… CONTINUE READING
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The DDB 1 - CUL 4 ADDB 2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H 2 A at UV - damaged DNA sites

  • M. G. Kapetanaki, J. Guerrero-Santoro, D. C. Bisi, C. L. Hsieh, V. Rapi ć-Otrin, A. S. Levine
  • Proc . Natl . Acad . Sci . USA .
  • 2006
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