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Organic Anion Transport Polypeptides

Known as: OATP Proteins, SLCO, Organic Anion-Transporting Polypeptide 
A family of transmembrane proteins that play a role in the transport of organic anions including bile acids and bilirubin.
National Institutes of Health

Related topics

Related topics

18 relations
Carrier ProteinsCellular MembraneIntegral Membrane ProteinsIonophore activity
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Broader (1)

Organic Anion Transporters

Papers overview

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Highly Cited
2005
Highly Cited
2005
Organic anion transporting polypeptides expressed in liver and brain mediate uptake of microcystin.
Microcystins are toxins produced by freshwater cyanobacteria. They are cyclic heptapeptides that exhibit hepato- and… Expand
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Review
2003
Review
2003
Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties
The organic anion transporting polypeptides (rodents: Oatps, human: OATPs) form a superfamily of sodium-independent transport… Expand
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Highly Cited
2002
Highly Cited
2002
Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine.
OBJECTIVES Our objective was to examine the effect of different fruits and their constituents on P-glycoprotein and organic anion… Expand
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Highly Cited
2001
Highly Cited
2001
Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver.
BACKGROUND & AIMS Hepatic uptake of cholephilic organic compounds is mediated by members of the organic anion-transporting… Expand
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Highly Cited
2000
Highly Cited
2000
A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane.
We cloned and expressed a new organic anion transporting polypeptide (OATP), termed human OATP2, (OATP-C, LST-1; symbol SLC21A6… Expand
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Highly Cited
2000
Highly Cited
2000
Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide.
Based on sequence homology to the human organic anion transporting polypeptide 2 (OATP2; SLC21A6), we cloned a new member of the… Expand
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Highly Cited
2000
Highly Cited
2000
Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.
We identified three novel transporters structurally belonging to the organic anion transporting polypeptide (OATP) family in… Expand
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Highly Cited
1999
Highly Cited
1999
A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human…
A novel human organic transporter, OATP2, has been identified that transports taurocholic acid, the adrenal androgen… Expand
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Highly Cited
1999
Highly Cited
1999
MRP3, an organic anion transporter able to transport anti-cancer drugs.
The human multidrug-resistance protein (MRP) gene family contains at least six members: MRP1, encoding the multidrug-resistance… Expand
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Highly Cited
1997
Highly Cited
1997
Expression cloning and characterization of a novel multispecific organic anion transporter.
Numerous drugs and endogenous compounds are efficiently excreted from the renal proximal tubule via carrier-mediated pathways… Expand
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