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- Publications
- Influence
Isolation and genetic characterization of human KB cell lines resistant to multiple drugs
- S. Akiyama, A. Fojo, J. Hanover, I. Pastan, M. Gottesman
- Biology, Medicine
- Somatic cell and molecular genetics
- 1 March 1985
Human KB cell lines resistant to high levels of colchicine were isolated by several successive single-step selections. Most of these selection steps resulted in cross-resistance to vincristine,… Expand
Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair
- Y. Takebayashi, P. Pourquier, +9 authors Y. Pommier
- Biology, Medicine
- Nature Medicine
- 1 August 2001
While investigating the novel anticancer drug ecteinascidin 743 (Et743), a natural marine product isolated from the Caribbean sea squirt, we discovered a new cell-killing mechanism mediated by DNA… Expand
Copper-transporting P-type adenosine triphosphatase (ATP7B) is associated with cisplatin resistance.
- M. Komatsu, T. Sumizawa, +8 authors S. Akiyama
- Biology, Medicine
- Cancer research
- 1 March 2000
The accumulation of cisplatin is decreased in many cisplatin-resistant cell lines, and an active efflux pump for cisplatin exists in some of them, but it has not yet been identified. In this study,… Expand
Fibronectin's cell-adhesive domain and an amino-terminal matrix assembly domain participate in its assembly into fibroblast pericellular matrix.
- J. A. Mcdonald, B. Quade, +4 authors S. Akiyama
- Medicine, Biology
- The Journal of biological chemistry
- 5 March 1987
Fibroblasts organize the modular cell-adhesive glycoprotein fibronectin into a highly structured pericellular matrix by poorly understood mechanisms. Previous studies implicated an amino-terminal… Expand
Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma.
- Y. Takebayashi, S. Akiyama, +6 authors T. Aikou
- Medicine
- Journal of the National Cancer Institute
- 21 August 1996
BACKGROUND
Platelet-derived endothelial cell growth factor (PD-ECGF) is known to promote the development of new blood vessels, which are fundamental to tumor growth and metastasis. We previously… Expand
A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells.
The human cMOAT gene encodes a membrane protein involved in the ATP-dependent transport of hydrophobic compounds. To determine whether cMOAT is associated with drug sensitivity, we transfected an… Expand
Involvement of mitogen-activated protein kinase signaling pathways in microcystin-LR-induced apoptosis after its selective uptake mediated by OATP1B1 and OATP1B3.
- Masaharu Komatsu, T. Furukawa, +6 authors T. Takeuchi
- Medicine, Biology
- Toxicological sciences : an official journal of…
- 1 June 2007
The serine/threonine protein phosphatase (PP) 2A inhibitor, microcystin-LR, selectively induces liver damage and promotes hepatocarcinogenesis. It is thought that microcystin-LR affects… Expand
Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane.
- Jill K. Paterson, S. Shukla, +10 authors M. Gottesman
- Biology, Medicine
- Biochemistry
- 28 July 2007
Expression of the ATP-binding cassette transporter ABCB6 has been associated with multiple cellular functions, including resistance to several cytotoxic agents, iron homeostasis, and porphyrin… Expand
A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation.
- K. Taniguchi, M. Wada, +7 authors M. Kuwano
- Biology, Medicine
- Cancer research
- 15 September 1996
By targeting the ATP binding conserved domain in three ATP binding cassette superfamily proteins (P-glycoprotein, multidrug resistance protein, and cystic fibrosis transmembrane regulator), we… Expand
The effect of a thymidine phosphorylase inhibitor on angiogenesis and apoptosis in tumors.
- S. Matsushita, T. Nitanda, +10 authors S. Akiyama
- Biology, Medicine
- Cancer research
- 15 April 1999
Thymidine phosphorylase (TP) is an enzyme involved in the reversible conversion of thymidine to thymine and is identical to an angiogenic factor, platelet-derived endothelial cell growth factor. TP… Expand