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Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

Human KB cell lines resistant to high levels of colchicine were isolated by several successive single-step selections. Most of these selection steps resulted in cross-resistance to vincristine,…
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Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter.

TLDR
It is found that LLC/cMOAT-1 cells have increased resistance to vincristine (VCR), 7-ethyl-10-hydroxy-camptothecin, and cisplatin but not to etoposide, and it is demonstrated that cMOAT confers a novel drug-resistance phenotype.
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A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation.

TLDR
The cDNA of a new ATP binding cassette superfamily that was specifically enhanced in a cisplatin-resistant human head and neck cancer KB cell line was isolated and a human clone homologous to rat canalicular multispecific organic anion transporter (cMOAT) was found and designated human cMOAT.
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Copper-transporting P-type adenosine triphosphatase (ATP7B) is associated with cisplatin resistance.

TLDR
Transfected the copper-transporting P-type ATPase cDNA into human epidermoid carcinoma KB-3-1 cells and found that KB/WD cells were sensitive to other heavy metals, such as antimony, arsenate, arsenite, cadmium, and cobalt, and ATP7B may be involved in cisplatin resistance in some tumors.
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Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair

TLDR
It is found that Et743 interacts with the transcription-coupled NER machinery to induce lethal DNA strand breaks, and studies of cells deficient in XPC or in the genes implicated in Cockayne syndrome indicated that the drug sensitivity is specifically dependent on the transcription and NER pathway.
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Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2)

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Involvement of mitogen-activated protein kinase signaling pathways in microcystin-LR-induced apoptosis after its selective uptake mediated by OATP1B1 and OATP1B3.

TLDR
It is demonstrated that microcystin-LR induces apoptosis through activation of multiple MAPK pathways subsequent to its selective uptake via OATP1B1 and OATp1B3 and followed by inhibition of PP2A, in addition to the ROS generation which might contribute to apoptosis.
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A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells.

TLDR
Results suggest that cMOAT levels are inversely correlated with those of glutathione, and that c MOAT and its related genes may be involved in the sensitivity of cells to certain anticancer agents.
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Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors.

TLDR
A high level of BCRP expression in CD4+ T cells conferred cellular resistance to human immunodeficiency virus type-1 (HIV-1) nucleoside reverse transcriptase inhibitors, and an analysis for intracellular metabolism of AZT suggests that the resistance is attributed to the increase of ATP-dependent efflux of its metabolites.
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Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane.

TLDR
These studies are the first to demonstrate that ABCB6 exists in two molecular weight forms, is localized to both the outer mitochondrial membrane and the plasma membrane, and plays a functional role in the Plasma membrane.
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