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Isolation and genetic characterization of human KB cell lines resistant to multiple drugs
- S. Akiyama, A. Fojo, J. Hanover, I. Pastan, M. Gottesman
- Biology, Medicine
- Somatic cell and molecular genetics
- 1 March 1985
Human KB cell lines resistant to high levels of colchicine were isolated by several successive single-step selections. Most of these selection steps resulted in cross-resistance to vincristine,… Expand
Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair
While investigating the novel anticancer drug ecteinascidin 743 (Et743), a natural marine product isolated from the Caribbean sea squirt, we discovered a new cell-killing mechanism mediated by DNA… Expand
Copper-transporting P-type adenosine triphosphatase (ATP7B) is associated with cisplatin resistance.
The accumulation of cisplatin is decreased in many cisplatin-resistant cell lines, and an active efflux pump for cisplatin exists in some of them, but it has not yet been identified. In this study,… Expand
Fibronectin's cell-adhesive domain and an amino-terminal matrix assembly domain participate in its assembly into fibroblast pericellular matrix.
- J. A. Mcdonald, B. Quade, +4 authors S. Akiyama
- Medicine, Biology
- The Journal of biological chemistry
- 5 March 1987
Fibroblasts organize the modular cell-adhesive glycoprotein fibronectin into a highly structured pericellular matrix by poorly understood mechanisms. Previous studies implicated an amino-terminal… Expand
Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma.
- Y. Takebayashi, S. Akiyama, +6 authors T. Aikou
- Journal of the National Cancer Institute
- 21 August 1996
BACKGROUND Platelet-derived endothelial cell growth factor (PD-ECGF) is known to promote the development of new blood vessels, which are fundamental to tumor growth and metastasis. We previously… Expand
A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells.
The human cMOAT gene encodes a membrane protein involved in the ATP-dependent transport of hydrophobic compounds. To determine whether cMOAT is associated with drug sensitivity, we transfected an… Expand
Involvement of mitogen-activated protein kinase signaling pathways in microcystin-LR-induced apoptosis after its selective uptake mediated by OATP1B1 and OATP1B3.
- Masaharu Komatsu, T. Furukawa, +6 authors T. Takeuchi
- Medicine, Biology
- Toxicological sciences : an official journal of…
- 1 June 2007
The serine/threonine protein phosphatase (PP) 2A inhibitor, microcystin-LR, selectively induces liver damage and promotes hepatocarcinogenesis. It is thought that microcystin-LR affects… Expand
Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane.
Expression of the ATP-binding cassette transporter ABCB6 has been associated with multiple cellular functions, including resistance to several cytotoxic agents, iron homeostasis, and porphyrin… Expand
A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation.
By targeting the ATP binding conserved domain in three ATP binding cassette superfamily proteins (P-glycoprotein, multidrug resistance protein, and cystic fibrosis transmembrane regulator), we… Expand
The effect of a thymidine phosphorylase inhibitor on angiogenesis and apoptosis in tumors.
Thymidine phosphorylase (TP) is an enzyme involved in the reversible conversion of thymidine to thymine and is identical to an angiogenic factor, platelet-derived endothelial cell growth factor. TP… Expand