• Publications
  • Influence
In vitro cell migration and invasion assays.
Determining the migratory and invasive capacity of tumor and stromal cells and clarifying the underlying mechanisms is most relevant for novel strategies in cancer diagnosis, prognosis, drugExpand
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Initial steps of metastasis: Cell invasion and endothelial transmigration
Metastasis is the leading cause of cancer mortality. The metastatic cascade represents a multi-step process which includes local tumor cell invasion, entry into the vasculature followed by the exitExpand
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Altered expression of organic anion transporter polypeptide (OATP) genes in human breast carcinoma
Organic anion transporter polypeptides (OATPs) mediate the transmembrane uptake of endogenous compounds and clinically important drugs in various tissues thereby effecting drug disposition and tissueExpand
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Gallic acid inhibits ribonucleotide reductase and cyclooxygenases in human HL-60 promyelocytic leukemia cells.
Gallic acid (GA) is a naturally occurring polyhydroxyphenolic compound and an excellent free radical scavenger. In this study, we examined its cytotoxic and biochemical effects on the human HL-60Expand
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Derivation of nephrogenic adenomas from renal tubular cells in kidney-transplant recipients.
BACKGROUND Nephrogenic adenomas are benign, tumor-like lesions within the urothelial mucosa of the urinary tract that are not uncommon in renal-transplant recipients. We investigated the origin ofExpand
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The evolution of cell death programs as prerequisites of multicellularity.
One of the hallmarks of multicellularity is that the individual cellular fate is sacrificed for the benefit of a higher order of life-the organism. The accidental death of cells in a multicellularExpand
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Effects on inflammatory responses by the sphingoid base 4,8-sphingadienine.
Sphingolipids (SLs) are a class of lipids, which are structural cell components involved in the regulation of cellular processes such as cell proliferation, differentiation, Expand
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Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT–mTOR–S6K signaling and drug responses
ABSTRACT Three-dimensional (3D) cancer models are used as preclinical systems to mimic physiologic drug responses. We provide evidence for strong changes of proliferation and metabolic capacity inExpand
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Bidirectional interactions between the estrogen receptor and the c‐erbB‐2 signaling pathways: Heregulin inhibits estrogenic effects in breast cancer cells
Thde responsiveness of estrogen receptor (ER)‐positive breast cancer to endocrine therapy is frequently reduced ihd cells over‐expressing c‐erbB‐2. Stimulation of ER suppresses c‐erbB‐2, indicatingExpand
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The ribonucleotide reductase inhibitor trimidox induces c-myc and apoptosis of human ovarian carcinoma cells.
Trimidox (3,4,5-trihydroxybenzohydroxamidoxime), a recently synthesized inhibitor of ribonucleotide reductase (RR), was shown to exert anti-proliferative activities in HL-60 and K562 human leukemiaExpand
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