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ORC1L protein, human

Known as: Origin Recognition Complex Subunit 1-Like, Origin Recognition Complex Subunit 1, origin recognition complex, subunit 1, human 
Origin recognition complex subunit 1 (861 aa, ~97 kDa) is encoded by the human ORC1 gene. This protein plays a role in DNA replication.
National Institutes of Health

Related topics

Related topics

12 relations
Cell CycleCell Cycle ControlCell Viability ProcessDNA-Binding Proteins

Broader (1)

origin recognition complex

Papers overview

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Highly Cited
2012
Highly Cited
2012
ORC1 BAH domain links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome
The recognition of distinctly modified histones by specialized ‘effector’ proteins constitutes a key mechanism for transducing… 
Highly Cited
2009
Highly Cited
2009
TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres.
Highly Cited
2009
Highly Cited
2009
Orc1 Controls Centriole and Centrosome Copy Number in Human Cells
Centrosomes, each containing a pair of centrioles, organize microtubules in animal cells, particularly during mitosis. DNA and… 
Highly Cited
2007
Highly Cited
2007
Structural Basis of DNA Replication Origin Recognition by an ORC Protein
DNA replication in archaea and in eukaryotes share many similarities. We report the structure of an archaeal origin recognition… 
Highly Cited
2004
Highly Cited
2004
Identification of Two Origins of Replication in the Single Chromosome of the Archaeon Sulfolobus solfataricus
Review
2003
Review
2003
The 'ORC cycle': a novel pathway for regulating eukaryotic DNA replication.
Highly Cited
2001
Highly Cited
2001
Replication Factors MCM2 and ORC1 Interact with the Histone Acetyltransferase HBO1*
The minichromosome maintenance (MCM) proteins, together with the origin recognition complex (ORC) proteins and Cdc6, play an… 
Highly Cited
1999
Highly Cited
1999
The BAH (bromo‐adjacent homology) domain: a link between DNA methylation, replication and transcriptional regulation
Highly Cited
1998
Highly Cited
1998
Human CDC6/Cdc18 Associates with Orc1 and Cyclin-cdk and Is Selectively Eliminated from the Nucleus at the Onset of S Phase
ABSTRACT In a two-hybrid screen for proteins that interact with human PCNA, we identified and cloned a human protein (hCdc18… 
Highly Cited
1994
Highly Cited
1994
Kin recognition between medial Golgi enzymes in HeLa cells.
The medial Golgi enzymes, N‐acetylglucosaminyltransferase I (NAGT I) and mannosidase II (Mann II), and the trans Golgi enzyme… 
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