origin recognition complex

We report that a highly purified human origin recognition complex (HsORC) has intrinsic DNA-binding activity, and that this… (More)

The MCM2-7 complex is believed to function as the eukaryotic replicative DNA helicase. It is recruited to chromatin by the origin… (More)

The E2F transcription factor and retinoblastoma protein control cell-cycle progression and DNA replication during S phase… (More)

Evidence obtained from studies with yeast and Xenopus indicate that the initiation of DNA replication is a multistep process. The… (More)

Using a combination of computer methods for iterative database searches and multiple sequence alignment, we show that protein… (More)

The origin recognition complex (ORC) is required to initiate eukaryotic DNA replication and also engages in transcriptional… (More)

In many organisms, the replication of DNA requires the binding of a protein called the initiator to DNA sites referred to as… (More)

The genes encoding two of the subunits of the Saccharomyces cerevisiae origin recognition complex (ORC) have been isolated… (More)

Here a method is described to identify genes encoding proteins that recognize a specific DNA sequence. A bank of random protein… (More)

A multiprotein complex that specifically recognizes cellular origins of DNA replication has been identified and purified from the… (More)