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origin recognition complex

Known as: Origin Recognition Complex [Chemical/Ingredient] 
The origin recognition complex is a multi-subunit DNA-binding protein that initiates DNA REPLICATION in eukaryotes.
National Institutes of Health

Related topics

Related topics

20 relations
In BloodProcess of secretionagonistsantagonists & inhibitors

Narrower (10)

ORC1L protein, humanORC2L protein, humanORC3 protein, humanORC4L protein, human

Broader (1)

Repressor Proteins

Papers overview

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2004
2004
The B-Subunit of DNA Polymerase α-Primase Associates with the Origin Recognition Complex for Initiation of DNA Replication
ABSTRACT The B-subunit (p70/Pol12p) of the DNA polymerase α-primase (Polα-primase) complex is thought to have a regulatory role… 
Highly Cited
2003
Highly Cited
2003
Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.
Highly Cited
2003
Highly Cited
2003
Degradation of origin recognition complex large subunit by the anaphase‐promoting complex in Drosophila
The initiation of DNA synthesis is thought to occur at sites bound by a heteromeric origin recognition complex (ORC). Previously… 
Highly Cited
2002
Highly Cited
2002
Purification and characterization of the Schizosaccharomyces pombe origin recognition complex: interaction with origin DNA and Cdc18 protein.
The origin recognition complex (ORC) plays a central role in the initiation of DNA replication in eukaryotic cells. It interacts… 
Highly Cited
2001
Highly Cited
2001
Control of DNA Rereplication via Cdc2 Phosphorylation Sites in the Origin Recognition Complex
ABSTRACT Cdc2 kinase is a master regulator of cell cycle progression in the fission yeast Schizosaccharomyces pombe. Our data… 
Highly Cited
2001
Highly Cited
2001
Two Compound Replication Origins in Saccharomyces cerevisiae Contain Redundant Origin Recognition Complex Binding Sites
ABSTRACT While many of the proteins involved in the initiation of DNA replication are conserved between yeasts and metazoans, the… 
Highly Cited
2001
Highly Cited
2001
Orc mutants arrest in metaphase with abnormally condensed chromosomes.
The origin recognition complex (ORC) is a six subunit complex required for eukaryotic DNA replication initiation and for… 
2000
2000
Interaction of Xenopus Cdc2·Cyclin A1 with the Origin Recognition Complex*
The initiation of DNA replication in eukaryotes is regulated in a minimum of at least two ways. First, several proteins… 
Review
1999
Review
1999
The metazoan origin recognition complex.
Regulated initiation of DNA replication relies on the firing of initiator proteins that bind specifically to origin DNA. The… 
1999
1999
Induction by Adozelesin and Hydroxyurea of Origin Recognition Complex-dependent DNA Damage and DNA Replication Checkpoints in Saccharomyces cerevisiae *
DNA damaging agents induce a conserved intra-S-phase checkpoint that inhibits DNA replication in eukaryotic cells. To better… 
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