origin recognition complex

Known as: Origin Recognition Complex [Chemical/Ingredient] 
The origin recognition complex is a multi-subunit DNA-binding protein that initiates DNA REPLICATION in eukaryotes.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1992-2018
0204019922018

Papers overview

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Highly Cited
2003
Highly Cited
2003
We report that a highly purified human origin recognition complex (HsORC) has intrinsic DNA-binding activity, and that this… (More)
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Highly Cited
2002
Highly Cited
2002
The MCM2-7 complex is believed to function as the eukaryotic replicative DNA helicase. It is recruited to chromatin by the origin… (More)
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Highly Cited
2001
Highly Cited
2001
The E2F transcription factor and retinoblastoma protein control cell-cycle progression and DNA replication during S phase… (More)
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Highly Cited
2000
Highly Cited
2000
Evidence obtained from studies with yeast and Xenopus indicate that the initiation of DNA replication is a multistep process. The… (More)
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Highly Cited
1999
Highly Cited
1999
Using a combination of computer methods for iterative database searches and multiple sequence alignment, we show that protein… (More)
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Highly Cited
1997
Highly Cited
1997
The origin recognition complex (ORC) is required to initiate eukaryotic DNA replication and also engages in transcriptional… (More)
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Highly Cited
1997
Highly Cited
1997
In many organisms, the replication of DNA requires the binding of a protein called the initiator to DNA sites referred to as… (More)
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Highly Cited
1993
Highly Cited
1993
The genes encoding two of the subunits of the Saccharomyces cerevisiae origin recognition complex (ORC) have been isolated… (More)
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Highly Cited
1993
Highly Cited
1993
Here a method is described to identify genes encoding proteins that recognize a specific DNA sequence. A bank of random protein… (More)
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Highly Cited
1992
Highly Cited
1992
A multiprotein complex that specifically recognizes cellular origins of DNA replication has been identified and purified from the… (More)
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