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origin recognition complex
Known as:
Origin Recognition Complex [Chemical/Ingredient]
The origin recognition complex is a multi-subunit DNA-binding protein that initiates DNA REPLICATION in eukaryotes.
National Institutes of Health
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Related topics
Related topics
20 relations
In Blood
Process of secretion
agonists
antagonists & inhibitors
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Narrower (10)
ORC1L protein, human
ORC2L protein, human
ORC3 protein, human
ORC4L protein, human
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Broader (1)
Repressor Proteins
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
CDK Phosphorylation Inhibits the DNA-binding and ATP-hydrolysis Activities of the Drosophila Origin Recognition Complex*
Dirk Remus
,
M. Blanchette
,
D. Rio
,
M. Botchan
Journal of Biological Chemistry
2005
Corpus ID: 24841225
Faithful propagation of eukaryotic chromosomes usually requires that no DNA segment be replicated more than once during one cell…
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2004
2004
The B-Subunit of DNA Polymerase α-Primase Associates with the Origin Recognition Complex for Initiation of DNA Replication
M. Uchiyama
,
T. Wang
Molecular and Cellular Biology
2004
Corpus ID: 23820837
ABSTRACT The B-subunit (p70/Pol12p) of the DNA polymerase α-primase (Polα-primase) complex is thought to have a regulatory role…
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2004
2004
Atomic force microscopic analysis of the binding of the Schizosaccharomyces pombe origin recognition complex and the spOrc4 protein with origin DNA
M. Gaczynska
,
P. Osmulski
,
Y. Jiang
,
Joon‐Kyu Lee
,
V. Bermudez
,
J. Hurwitz
Proceedings of the National Academy of Sciences…
2004
Corpus ID: 35892239
In eukaryotes, the initiation of DNA replication requires the interaction between origin sequences and the origin recognition…
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Highly Cited
2003
Highly Cited
2003
Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.
Margot Kneissl
,
V. Pütter
,
A. Szalay
,
F. Grummt
Journal of Molecular Biology
2003
Corpus ID: 26296241
Highly Cited
2003
Highly Cited
2003
Degradation of origin recognition complex large subunit by the anaphase‐promoting complex in Drosophila
Marito Araki
,
R. Wharton
,
Zhanyun Tang
,
Hongtao Yu
,
M. Asano
EMBO Journal
2003
Corpus ID: 22230447
The initiation of DNA synthesis is thought to occur at sites bound by a heteromeric origin recognition complex (ORC). Previously…
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Highly Cited
2002
Highly Cited
2002
Purification and characterization of the Schizosaccharomyces pombe origin recognition complex: interaction with origin DNA and Cdc18 protein.
R. Chuang
,
L. Chrétien
,
Jianli Dai
,
T. Kelly
Journal of Biological Chemistry
2002
Corpus ID: 28066927
The origin recognition complex (ORC) plays a central role in the initiation of DNA replication in eukaryotic cells. It interacts…
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2002
2002
Involvement of RAD9-Dependent Damage Checkpoint Control in Arrest of Cell Cycle, Induction of Cell Death, and Chromosome Instability Caused by Defects in Origin Recognition Complex in Saccharomyces…
Keiichi Watanabe
,
Jun Morishita
,
K. Umezu
,
K. Shirahige
,
H. Maki
Eukaryotic Cell
2002
Corpus ID: 2772976
ABSTRACT Perturbation of origin firing in chromosome replication is a possible cause of spontaneous chromosome instability in…
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Highly Cited
2001
Highly Cited
2001
Two Compound Replication Origins in Saccharomyces cerevisiae Contain Redundant Origin Recognition Complex Binding Sites
J. Theis
,
C. Newlon
Molecular and Cellular Biology
2001
Corpus ID: 31418752
ABSTRACT While many of the proteins involved in the initiation of DNA replication are conserved between yeasts and metazoans, the…
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2000
2000
Interaction of Xenopus Cdc2·Cyclin A1 with the Origin Recognition Complex*
P. Romanowski
,
Jackie Marr
,
+4 authors
R. Laskey
Journal of Biological Chemistry
2000
Corpus ID: 24230938
The initiation of DNA replication in eukaryotes is regulated in a minimum of at least two ways. First, several proteins…
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Review
1999
Review
1999
The metazoan origin recognition complex.
David G. Quintana
,
Anindya Dutta
Frontiers in Bioscience
1999
Corpus ID: 13335472
Regulated initiation of DNA replication relies on the firing of initiator proteins that bind specifically to origin DNA. The…
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