• Publications
  • Influence
Simian virus 40 DNA replication in vitro.
  • J. Li, T. Kelly
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 November 1984
TLDR
The system provides a biochemical assay for the replication activity of SV40 T antigen and should also facilitate the purification and functional characterization of cellular proteins involved in DNA replication. Expand
Regulation of chromosome replication.
TLDR
The checkpoint mechanisms that function to preserve the integrity of the genome when the normal course of genome duplication is perturbed by factors that damage the DNA or inhibit DNA synthesis are described. Expand
A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication
TLDR
It is concluded that CTF/NF-I can serve both as a transcription selectivity factor for RNA polymerase II and as an initiation factor for adenovirus DNA replication. Expand
Interaction of DNA polymerase alpha‐primase with cellular replication protein A and SV40 T antigen.
TLDR
The results suggest that the specific protein‐protein interactions between RP‐A, polymerase‐primase and T antigen may play a role in the initiating of SV40 DNA replication. Expand
The fission yeast cdc18 + gene product couples S phase to START and mitosis
Commitment to the cell cycle in fission yeast requires the function of the cdc10+ transcriptional activator at START. The product of the cdc18+ gene is a major downstream target of cdc10+, andExpand
Purification and characterization of replication protein A, a cellular protein required for in vitro replication of simian virus 40 DNA.
  • M. Wold, T. Kelly
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 April 1988
TLDR
The purification of one of these proteins, replication protein A (RP-A), to homogeneity is reported, consistent with the possibility that RP-A plays a central role in the generation of a single-stranded region at the origin prior to initiation of DNA synthesis. Expand
Assembly of the Human Origin Recognition Complex*
TLDR
The characterization of HsORC should facilitate the identification of human origins of DNA replication and suggest that the subunits HsOrc2, Hs orc3, and Hs Orc4 form a core upon which the ordered assembly of H sOrc5 and HSOrc1 takes place. Expand
Purification of Hsk1, a Minichromosome Maintenance Protein Kinase from Fission Yeast*
TLDR
The purified Hsk1 kinase phosphorylates the Cdc19 (Mcm2) subunit of the six-member minichromosome maintenance protein complex purified from fission yeast, suggesting that the essential function of HSk1 at the G1/S transition may be mediated by phosphorylation of CDC19. Expand
Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation.
Cyclin-dependent kinases (CDKs) promote the initiation of DNA replication and prevent reinitiation before mitosis, presumably through phosphorylation of key substrates at origins of replication. InExpand
The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast.
TLDR
The results indicate a functional similarity between MEC1 and ATM, and suggest that RPA phosphorylation is involved in a conserved eukaryotic DNA damage-response pathway defective in A-T. Expand
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