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HUMAN DISEASE
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Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development
TLDR
Tead4 is the earliest gene shown to be uniquely required for specification of the trophectoderm lineage, and one of two highly homologous TEAD transcription factors that are expressed during zygotic gene activation in mouse 2-cell embryos.
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TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm.
TLDR
It is proposed that YAP65 regulates TEAD-dependent transcription in response to mitogenic signals, and YAP 65 also binds Src/Yes protein tyrosine kinases, and the carboxy-terminal acidic activation domain in YAP is the transcriptional activation domain for TEAD transcription factors.
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Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors
TLDR
It is shown that SoxC survival critically relies on the redundantly acting SoxC transcription factors Sox4, Sox11 and Sox12, which ensure neural and mesenchymal progenitor cell survival and function in part by activating this transcriptional mediator of the Hippo signalling pathway.
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Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity.
TLDR
It is shown that RO3306 inhibition of cyclin-dependent protein kinase 1 (CDK1), the enzyme required to enter mitosis, induced differentiation of TS cells into TG cells, and triggered endoreduplication in TS cells is triggered by p57 inhibition of CDK1 with concomitant suppression of the DNA damage response by p21.
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Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex
TLDR
It is shown that the biochemical composition and stoichiometry of the human RNase H2 complex is consistent with the properties previously deduced from genetic studies, and a role for the C subunit in enzymatic activity is revealed.
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The 'ORC cycle': a novel pathway for regulating eukaryotic DNA replication.
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Regulating the licensing of DNA replication origins in metazoa.
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Replication origins in metazoan chromosomes: fact or fiction?
  • M. DePamphilis
  • Biology
    BioEssays : news and reviews in molecular…
  • 1 January 1999
TLDR
Recent results strongly support the view that DNA replication origins in metazoan chromosomes consist of one or more high frequency initiation sites and perhaps several low frequency ones that together can appear as a nonspecific initiation zone.
View on Wiley
Identification of Primary Initiation Sites for DNA Replication in the Hamster Dihydrofolate Reductase Gene Initiation Zone
TLDR
The DHFR gene initiation zone contains at least three primary initiation sites, suggesting that initiation zones in mammals, like those in fission yeast, consist of multiple replication origins.
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