Oncogenic pathway signatures in human cancers as a guide to targeted therapies
It is shown that gene expression signatures can be identified that reflect the activation status of several oncogenic pathways and linked with sensitivity to therapeutics that target components of the pathway provides an opportunity to make use of these oncogens pathway signatures to guide the use of targeted therapeutics.
High-Dimensional Sparse Factor Modeling: Applications in Gene Expression Genomics
- C. Carvalho, Jeffrey Chang, J. Lucas, J. Nevins, Quanli Wang, M. West
- Computer Science, BiologyJournal of the American Statistical Association
- 1 December 2008
These case studies aim to investigate and characterize heterogeneity of structure related to specific oncogenic pathways, as well as links between aggregate patterns in gene expression profiles and clinical biomarkers.
Predicting the clinical status of human breast cancer by using gene expression profiles
- M. West, C. Blanchette, J. Nevins
- BiologyProceedings of the National Academy of Sciences…
- 18 September 2001
Bayesian regression models that provide predictive capability based on gene expression data derived from DNA microarray analysis of a series of primary breast cancer samples are developed and the utility and validity of such models in predicting the status of tumors in crossvalidation determinations are assessed.
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.
- R. Sears, F. Nuckolls, E. Haura, Y. Taya, K. Tamai, J. Nevins
- Biology, ChemistryGenes & Development
- 1 October 2000
A synergistic role for multiple Ras-mediated phosphorylation pathways in the control of Myc protein accumulation during the initial stage of cell proliferation is defined.
The E2F transcription factor is a cellular target for the RB protein
- S. Chellappan, S. Hiebert, M. Mudryj, J. Horowitz, J. Nevins
- BiologyCell
- 14 June 1991
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells
- Elisabeth S Yeh, M. Cunningham, R. Sears
- BiologyNature Cell Biology
- 1 April 2004
It is shown that Ser 62 is dephosphorylated by protein phosphatase 2A (PP2A) before ubiquitination of c-Myc, and that PP2A activity is regulated by the Pin1 prolyl isomerase, resulting in c- myc stabilization.
The Rb/E2F pathway and cancer.
- J. Nevins
- BiologyHuman Molecular Genetics
- 1 April 2001
It is now clear that the Rb/E2F pathway is critical in regulating the initiation of DNA replication and that the control of the pathway is disrupted in virtually all human cancers.
Distinct roles for E2F proteins in cell growth control and apoptosis.
- J. DeGregori, G. Leone, A. Miron, L. Jakoi, J. Nevins
- BiologyProceedings of the National Academy of Sciences…
- 8 July 1997
It is concluded that E 2F family members play distinct roles in cell cycle control and that E2F1 may function as a specific signal for the initiation of an apoptosis pathway that must normally be blocked for a productive proliferation event.
Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes
- J. DeGregori, T. Kowalik, J. Nevins
- BiologyMolecular and Cellular Biology
- 1 August 1995
It is demonstrated that a G1 arrest brought about by gamma irradiation is overcome by the overexpression of E2F1 and that this coincides with the enhanced activation of key target genes, including the cyclin A and cyclin E genes.
GATHER: a systems approach to interpreting genomic signatures
- Jeffrey T. Chang, J. Nevins
- BiologyBioinform.
- 10 November 2006
GATHER is developed, a tool that integrates various forms of available data to elucidate biological context within molecular signatures produced from high-throughput post-genomic assays and provides an essential tool for extracting the full value from molecular signatures generated from genome-scale analyses.
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