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ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex
It is proposed that the origin recognition complex acts as the initiator protein for S. cerevisiae origins of DNA replication, and specific DNA binding by theorigin recognition complex is dependent upon the addition of ATP. Expand
A yeast chromosomal origin of DNA replication defined by multiple functional elements.
The multipartite nature of a chromosomal replication origin and the role of transcriptional activators in its function present a striking similarity to the organization of eukaryotic promoters. Expand
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
It is shown that p21 directly inhibits PCNA-dependent DNA replication in the absence of a cyclin/CDK, and blocks the ability of PCNA to activateDNA polymerase δ, the principal replicative DNA polymerase. Expand
Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis
Using centrifugal elutriation of several human cell lines, it is demonstrated that whereas human Orc2 and hMcm proteins are present throughout the cell cycle, hCdc6p levels vary, being very low in early G1 and accumulating until cells enter mitosis, indicating that the mitotic kinase activity inhibits prereplication complex formation in human cells. Expand
Replication-Dependent Marking of DNA by PCNA Facilitates CAF-1-Coupled Inheritance of Chromatin
It is demonstrated that after DNA replication, replicated, but not unreplicated, DNA is also competent for CAF-1-dependent chromatin assembly and suggested that PCNA and CAf-1 connect DNA replication to chromatinAssembly and the inheritance of epigenetic chromosome states. Expand
FASCIATA Genes for Chromatin Assembly Factor-1 in Arabidopsis Maintain the Cellular Organization of Apical Meristems
- H. Kaya, K. Shibahara, K. Taoka, M. Iwabuchi, B. Stillman, T. Araki
- Medicine, Biology
- 12 January 2001
It is suggested that CAF-1 plays a critical role in the organization of SAM and RAM during postembryonic development by facilitating stable maintenance of gene expression states. Expand
Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor-I.
The purification of CAF-I from the budding yeast Saccharomyces cerevisiae and Amino acid sequence data from purified yeast CAf-I led to identification of the genes encoding each subunit in the yeast genome data base, suggesting that CAF/CAC has been conserved functionally and structurally from yeast to human cells. Expand
Nucleosome Assembly by a Complex of CAF-1 and Acetylated Histones H3/H4
The data suggest that CAC is a key intermediate of the de novo nucleosome assembly pathway and that the p48 subunit participates in other aspects of histone metabolism. Expand
Heterochromatin dynamics in mouse cells: interaction between chromatin assembly factor 1 and HP1 proteins.
It is suggested that CAF-1 p150 has a heterochromatin-specific function distinct from its nucleosome assembly function during S phase, as histone H3 is dephosphorylated just before mitosis. Expand
The DNA replication fork in eukaryotic cells.
Biochemical studies, principally of plasmid DNAs containing the Simian Virus 40 origin of DNA replication, and yeast genetic studies have uncovered the fundamental mechanisms of replication fork progression. Expand