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ORC1 gene

Known as: origin recognition complex subunit 1, Origin Recognition Complex, Subunit 1-Like (Yeast) Gene, PARC1 
This gene plays a role in DNA binding, initiation of DNA replication and transcriptional silencing. It is also involved in ATP hydrolysis and the… 
National Institutes of Health

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Related topics

6 relations
Cell Viability ProcessDNA ReplicationORC1L protein, humanReplication Initiation

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ORC1L wt Allele

Papers overview

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Highly Cited
2011
Highly Cited
2011
Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79.
The silent information regulator 2/3/4 (Sir2/3/4) complex is required for gene silencing at the silent mating-type loci and at… 
Highly Cited
2009
Highly Cited
2009
Trypanosome Prereplication Machinery Contains a Single Functional Orc1/Cdc6 Protein, Which Is Typical of Archaea
ABSTRACT In unicellular eukaryotes, such as Saccharomyces cerevisiae, and in multicellular organisms, the replication origin is… 
Highly Cited
2008
Highly Cited
2008
Evolutionarily Conserved Transcriptional Co-Expression Guiding Embryonic Stem Cell Differentiation
Background Understanding the molecular mechanisms controlling pluripotency in embryonic stem cells (ESCs) is of central… 
Highly Cited
2006
Highly Cited
2006
Latency-Associated Nuclear Antigen (LANA) of Kaposi's Sarcoma-Associated Herpesvirus Interacts with Origin Recognition Complexes at the LANA Binding Sequence within the Terminal Repeats
ABSTRACT Kaposi's sarcoma-associated herpesvirus (KSHV) DNA persists in latently infected cells as an episome via tethering to… 
Highly Cited
2004
Highly Cited
2004
Genome based identification and analysis of the pre‐replicative complex of Arabidopsis thaliana
Highly Cited
2000
Highly Cited
2000
Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M–G1 transition in mammals
To investigate the events leading to initiation of DNA replication in mammalian chromosomes, the time when hamster origin… 
Highly Cited
2000
Highly Cited
2000
Association of Human Origin Recognition Complex 1 with Chromatin DNA and Nuclease-resistant Nuclear Structures*
An origin recognition complex (ORC) consisting of six polypeptides has been identified as a DNA replication origin-binding factor… 
Highly Cited
1999
Highly Cited
1999
The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells.
The Cdc6 protein of budding yeast and its homologues in other species play an essential role in the initiation of DNA replication… 
Highly Cited
1996
Highly Cited
1996
Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor
The initiation of DNA replication in Saccharomyces cerevisiae requires the action of a multisubunit complex of six proteins known… 
1993
1993
Differential expression of principal sigma factor homologues of Streptomyces aureofaciens correlates with the developmental stage.
In previous experiments, Streptomyces aureofaciens has been shown to contain four genes hrdA, hrdB, hrdD, and hrdE, encoding… 
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