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Replication Initiation

Known as: DNA replication initiation, DNA-dependent DNA replication initiation 
DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to… 
National Institutes of Health

Related topics

Related topics

50 relations
CDC45 geneCDC45L protein, humanCDC45L wt AlleleCDC6 gene

Broader (1)

DNA endoreduplication

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Cyclin-Dependent Kinase Suppression by WEE1 Kinase Protects the Genome through Control of Replication Initiation and Nucleotide Consumption
ABSTRACT Activation of oncogenes or inhibition of WEE1 kinase deregulates cyclin-dependent kinase (CDK) activity and leads to… 
Highly Cited
2011
Highly Cited
2011
Limiting replication initiation factors execute the temporal programme of origin firing in budding yeast
Eukaryotic chromosomes are replicated from multiple origins that initiate throughout the S‐phase of the cell cycle. Why all… 
Highly Cited
2010
Highly Cited
2010
Chk1 promotes replication fork progression by controlling replication initiation
DNA replication starts at initiation sites termed replication origins. Metazoan cells contain many more potential origins than… 
Highly Cited
2010
Highly Cited
2010
Checkpoint Dependent Inhibition of DNA Replication Initiation by Sld3 and Dbf4 Phosphorylation
The initiation of eukaryotic DNA replication is regulated by three protein kinase classes: cyclin-dependent kinases (CDK), Dbf4… 
Highly Cited
2007
Highly Cited
2007
The Intra-S-Phase Checkpoint Affects both DNA Replication Initiation and Elongation: Single-Cell and -DNA Fiber Analyses
ABSTRACT To investigate the contribution of DNA replication initiation and elongation to the intra-S-phase checkpoint, we… 
Review
2004
Review
2004
Eukaryotic MCM Proteins: Beyond Replication Initiation
SUMMARY The minichromosome maintenance (or MCM) protein family is composed of six related proteins that are conserved in all… 
Highly Cited
2004
Highly Cited
2004
ATR and ATM regulate the timing of DNA replication origin firing
Timing of DNA replication initiation is dependent on S-phase-promoting kinase (SPK) activity at discrete origins and the… 
Highly Cited
2001
Highly Cited
2001
Replication from oriP of Epstein-Barr Virus Requires Human ORC and Is Inhibited by Geminin
Highly Cited
1999
Highly Cited
1999
Cell Cycle–Dependent Polar Localization of an Essential Bacterial Histidine Kinase that Controls DNA Replication and Cell Division
Review
1994
Review
1994
Cell cycle regulated transcription in yeast.
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