Replication Initiation

Known as: DNA replication initiation, DNA-dependent DNA replication initiation 
DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
It has become increasingly clear that oncogenes not only provide aberrant growth signals to cells but also cause DNA damage at… (More)
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Highly Cited
2011
Highly Cited
2011
Common fragile sites have long been identified by cytogeneticists as chromosomal regions prone to breakage upon replication… (More)
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Highly Cited
2010
Highly Cited
2010
DNA replication starts at initiation sites termed replication origins. Metazoan cells contain many more potential origins than… (More)
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Highly Cited
2009
Highly Cited
2009
Genomic mapping of DNA replication origins (ORIs) in mammals provides a powerful means for understanding the regulatory… (More)
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Review
2004
Review
2004
The minichromosome maintenance (or MCM) protein family is composed of six related proteins that are conserved in all eukaryotes… (More)
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Highly Cited
2003
Highly Cited
2003
We report that a highly purified human origin recognition complex (HsORC) has intrinsic DNA-binding activity, and that this… (More)
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Highly Cited
2001
Highly Cited
2001
We identified a signaling pathway that prevents initiation of sporulation in Bacillus subtilis when replication initiation is… (More)
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Highly Cited
2001
Highly Cited
2001
The packaging of eukaryotic DNA into nucleosomes is a critical regulator of nuclear events. To address the interplay between… (More)
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Review
1999
Review
1999
The MCM proteins are essential replication initiation factors originally identified as proteins required for minichromosome… (More)
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Highly Cited
1994
Highly Cited
1994
In E. coli, replication initiates at a genetically unique origin, oriC. Rapidly growing cells contain multiple oriC copies… (More)
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