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CDC45 gene

Known as: CDC45, S. CEREVISIAE, HOMOLOG OF, CDC45-LIKE, CDC45 
This gene plays a role in the initiation of DNA replication.
National Institutes of Health

Related topics

Related topics

4 relations
CDC45L protein, humanDNA ReplicationReplication Initiation

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CDC45L wt Allele

Papers overview

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Highly Cited
2011
Highly Cited
2011
MCM2-7 Form Double Hexamers at Licensed Origins in Xenopus Egg Extract*
In late mitosis and G1, Mcm2-7 are assembled onto replication origins to license them for initiation in the upcoming S phase… 
Highly Cited
2006
Highly Cited
2006
Distinct roles for Sld3 and GINS during establishment and progression of eukaryotic DNA replication forks
The Cdc45 protein is crucial for the initiation of chromosome replication in eukaryotic cells, as it allows the activation of… 
Highly Cited
2006
Highly Cited
2006
The Chk1-mediated S-phase Checkpoint Targets Initiation Factor Cdc45 via a Cdc25A/Cdk2-independent Mechanism*
DNA damage induced by the carcinogen benzo[a]pyrene dihydrodiol epoxide (BPDE) induces a Chk1-dependent S-phase checkpoint. Here… 
Highly Cited
2004
Highly Cited
2004
The zinc-finger transcription factor GLI2 antagonizes contact inhibition and differentiation of human epidermal cells
In stratified epidermis, activation of the Hh/Gli signal transduction pathway has been implicated in the control of cell… 
Highly Cited
2001
Highly Cited
2001
Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae
Cdc45, which binds to the minichromosomal maintenance (Mcm) proteins, has a pivotal role in the initiation and elongation steps… 
Highly Cited
2001
Highly Cited
2001
Drosophila E2f2 promotes the conversion from genomic DNA replication to gene amplification in ovarian follicle cells.
Drosophila contains two members of the E2F transcription factor family (E2f and E2f2), which controls the expression of genes… 
Review
2000
Review
2000
Eukaryotic DNA replication: from pre-replication complex to initiation complex.
Highly Cited
1999
Highly Cited
1999
Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha.
Budding yeast CDC45 encodes Cdc45p, an essential protein required to trigger initiation of DNA replication in late G1 phase. We… 
Highly Cited
1999
Highly Cited
1999
A 22q11.2 deletion that excludes UFD1L and CDC45L in a patient with conotruncal and craniofacial defects.
This work was supported by National Institutes of Health grants DC02027 and HL51533 (to B.S.E, H.M., and E.H.Z.) and HD 26979 (to… 
Highly Cited
1997
Highly Cited
1997
CDC45 is required in conjunction with CDC7/DBF4 to trigger the initiation of DNA replication.
The initiation of DNA replication in Saccharomyces cerevisiae requires the protein product of the CDC45 gene. We report that… 
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