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CDC45 gene

Known as: CDC45, S. CEREVISIAE, HOMOLOG OF, CDC45-LIKE, CDC45 
This gene plays a role in the initiation of DNA replication.
National Institutes of Health

Related topics

Related topics

4 relations
CDC45L protein, humanDNA ReplicationReplication Initiation

Narrower (1)

CDC45L wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
The physical interaction of Mcm10 with Cdc45 modulates their DNA-binding properties.
The eukaryotic DNA replication protein Mcm10 (mini-chromosome maintenance 10) associates with chromatin in early S-phase and is… 
Review
2010
Review
2010
The initiation step of eukaryotic DNA replication.
Eukaryotic initiation of DNA replication is a tightly regulated process. In the yeasts, S-phase-specific cyclin Cdk1 complex as… 
2008
2008
Global analysis of gene expression changes during retinoic acid-induced growth arrest and differentiation of melanoma: comparison to differentially expressed genes in melanocytes vs melanoma
BackgroundThe incidence of malignant melanoma has significantly increased over the last decade. Some of these malignancies are… 
Highly Cited
2006
Highly Cited
2006
Protein Phosphatase 2A Antagonizes ATM and ATR in a Cdk2- and Cdc7-Independent DNA Damage Checkpoint
ABSTRACT We previously used a soluble cell-free system derived from Xenopus eggs to investigate the role of protein phosphatase… 
2004
2004
A novel intermediate in initiation complex assembly for fission yeast DNA replication.
Assembly of initiation factors on individual replication origins at onset of S phase is crucial for regulation of replication… 
2002
2002
The mcm5-bob1 bypass of Cdc7p/Dbf4p in DNA replication depends on both Cdk1-independent and Cdk1-dependent steps in Saccharomyces cerevisiae.
The roles in DNA replication of two distinct protein kinases, Cdc7p/Dbf4p and Cdk1p/Clb (B-type cyclin), were studied. This was… 
Highly Cited
1999
Highly Cited
1999
Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha.
Budding yeast CDC45 encodes Cdc45p, an essential protein required to trigger initiation of DNA replication in late G1 phase. We… 
Highly Cited
1999
Highly Cited
1999
DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae.
In addition to DNA polymerase complexes, DNA replication requires the coordinate action of a series of proteins, including… 
1998
1998
Identification of sna41 gene, which is the suppressor of nda4 mutation and is involved in DNA replication in Schizosaccharomyces pombe
The replication licensing factor limits DNA replication to once in a cell cycle and is thought to contain MCM proteins as its… 
Review
1996
Review
1996
Coordinating DNA replication with cell division: current status of the licensing concept.
The replication of the genetic material during cell doubling is regulated at three apparently distinct levels. In the eukaryote… 
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