CDC45 gene

Known as: CDC45, S. CEREVISIAE, HOMOLOG OF, CDC45-LIKE, CDC45 
This gene plays a role in the initiation of DNA replication.
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Two central steps for initiating eukaryotic DNA replication involve loading of the Mcm2–7 helicase onto double-stranded DNA and… (More)
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Highly Cited
2008
Highly Cited
2008
Polo-like kinase (Plk)1 is required for mitosis progression. However, although Plk1 is expressed throughout the cell cycle, its… (More)
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Highly Cited
2007
Highly Cited
2007
In eukaryotic cells, cyclin-dependent kinases (CDKs) have an important involvement at various points in the cell cycle. At the… (More)
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Highly Cited
2006
Highly Cited
2006
Origins of DNA replication are licensed in G1 by recruiting the minichromosome maintenance (MCM) proteins to form a… (More)
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Highly Cited
2005
Highly Cited
2005
The ATR-dependent DNA damage response pathway can respond to a diverse group of lesions as well as inhibitors of DNA replication… (More)
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Highly Cited
2005
Highly Cited
2005
Cdc45 is required for initiation of DNA replication and fork progression, but its function in these processes remains unknown. We… (More)
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Highly Cited
2002
Highly Cited
2002
The MCM2-7 complex is believed to function as the eukaryotic replicative DNA helicase. It is recruited to chromatin by the origin… (More)
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Highly Cited
2001
Highly Cited
2001
Cdc45, which binds to the minichromosomal maintenance (Mcm) proteins, has a pivotal role in the initiation and elongation steps… (More)
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1998
1998
In budding yeast Saccharomyces cerevisiae CDC45 is an essential gene required for initiation of DNA replication. A structurally… (More)
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1997
1997
The initiation of DNA replication in Saccharomyces cerevisiae requires the protein product of the CDC45 gene. We report that… (More)
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