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CDC45L protein, human

Known as: Cell Division Cycle 45, S. cerevisiae, Homolog-Like, CDC45-Like, CDC45 Cell Division Cycle 45-Like (S. cerevisiae) 
CDC45-related protein (566 aa, ~66 kDa) is encoded by the human CDC45L gene. This protein is involved in the initiation of genomic DNA replication.
National Institutes of Health

Related topics

Related topics

10 relations
CDC45 geneCDC45L wt AlleleCell CycleCell Cycle Control

Broader (1)

Cell Cycle Proteins

Papers overview

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Highly Cited
2016
Highly Cited
2016
Cdc45 is limiting for replication initiation in humans
ABSTRACT Cdc45 is an essential protein that together with Mcm2-7 and GINS forms the eukaryotic replicative helicase CMG. Cdc45… 
2016
2016
Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading
Recent studies have shown synergistic cytotoxic effects of simultaneous Chk1- and Wee1-inhibition. However, the mechanisms behind… 
2013
2013
The physical interaction of Mcm10 with Cdc45 modulates their DNA-binding properties.
The eukaryotic DNA replication protein Mcm10 (mini-chromosome maintenance 10) associates with chromatin in early S-phase and is… 
Highly Cited
2011
Highly Cited
2011
Auxin-inducible protein depletion system in fission yeast
BackgroundInducible inactivation of a protein is a powerful approach for analysis of its function within cells. Fission yeast is… 
2011
2011
Single-agent inhibition of Chk1 is antiproliferative in human cancer cell lines in vitro and inhibits tumor xenograft growth in vivo.
Chk1 is a serine/threonine kinase that plays several important roles in the cellular response to genotoxic stress. Since many… 
Highly Cited
2007
Highly Cited
2007
Interactions of human Cdc45 with the Mcm2–7 complex, the GINS complex, and DNA polymerases δ and ɛ during S phase
Cdc45 is an essential cellular protein that functions in both the initiation and elongation of DNA replication. Here, we analyzed… 
Highly Cited
2006
Highly Cited
2006
The Chk1-mediated S-phase Checkpoint Targets Initiation Factor Cdc45 via a Cdc25A/Cdk2-independent Mechanism*
DNA damage induced by the carcinogen benzo[a]pyrene dihydrodiol epoxide (BPDE) induces a Chk1-dependent S-phase checkpoint. Here… 
Highly Cited
2006
Highly Cited
2006
Protein Phosphatase 2A Antagonizes ATM and ATR in a Cdk2- and Cdc7-Independent DNA Damage Checkpoint
ABSTRACT We previously used a soluble cell-free system derived from Xenopus eggs to investigate the role of protein phosphatase… 
Highly Cited
1999
Highly Cited
1999
Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha.
Budding yeast CDC45 encodes Cdc45p, an essential protein required to trigger initiation of DNA replication in late G1 phase. We… 
Highly Cited
1997
Highly Cited
1997
CDC45 is required in conjunction with CDC7/DBF4 to trigger the initiation of DNA replication.
The initiation of DNA replication in Saccharomyces cerevisiae requires the protein product of the CDC45 gene. We report that… 
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