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CDC45L protein, human

Known as: Cell Division Cycle 45, S. cerevisiae, Homolog-Like, CDC45-Like, CDC45 Cell Division Cycle 45-Like (S. cerevisiae) 
CDC45-related protein (566 aa, ~66 kDa) is encoded by the human CDC45L gene. This protein is involved in the initiation of genomic DNA replication.
National Institutes of Health

Related topics

Related topics

10 relations
CDC45 geneCDC45L wt AlleleCell CycleCell Cycle Control

Broader (1)

Cell Cycle Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Initiation-specific alleles of the Cdc45 helicase-activating protein
The committed step in DNA replication initiation is the activation of the Mcm2-7 replicative DNA helicase. Two activators, Cdc45… 
2013
2013
The physical interaction of Mcm10 with Cdc45 modulates their DNA-binding properties.
The eukaryotic DNA replication protein Mcm10 (mini-chromosome maintenance 10) associates with chromatin in early S-phase and is… 
2013
2013
Activation of the Mcm2-7 helicase function by ancillary replication factors GINS and Cdc45
2012
2012
Establishing the human rolling circle reaction
Comment on: Kang YH, et al. Proc Natl Acad Sci USA 2012; 109:6042-7. 
Highly Cited
2006
Highly Cited
2006
Protein Phosphatase 2A Antagonizes ATM and ATR in a Cdk2- and Cdc7-Independent DNA Damage Checkpoint
ABSTRACT We previously used a soluble cell-free system derived from Xenopus eggs to investigate the role of protein phosphatase… 
2006
2006
The Chk 1-mediated S-phase Checkpoint Targets Initiation Factor Cdc 45 via a Cdc 25 A / Cdk 2-independent Mechanism *
DNA damage induced by the carcinogen benzo[a]pyrene dihydrodiol epoxide (BPDE) induces a Chk1-dependent S-phase checkpoint. Here… 
2006
2006
Roles of DNA polymerase epsilon and TopBP1 in DNA replication and damage response
During DNA replication cells accurately copy their DNA to transfer the genetic information to daughter cells. DNA polymerases… 
2006
2006
Der humane Replikationsfaktor Cdc45 : Lokalisation und Interaktionspartner
Cdc45 (cell division cycle protein 45) ist ein essentieller Replikationsfaktor, der in der Initiation und Elongation der DNA… 
Highly Cited
1999
Highly Cited
1999
Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha.
Budding yeast CDC45 encodes Cdc45p, an essential protein required to trigger initiation of DNA replication in late G1 phase. We… 
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