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BackgroundIn eukaryotes, the CMG (CDC45, MCM, GINS) complex containing the replicative helicase MCM is a key player in DNA… Expand In eukaryotic cells, cyclin-dependent kinases (CDKs) have an important involvement at various points in the cell cycle. At the… Expand DNA damage induced by the carcinogen benzo[a]pyrene dihydrodiol epoxide (BPDE) induces a Chk1-dependent S-phase checkpoint. Here… Expand Cdc45 is required for initiation of DNA replication and fork progression, but its function in these processes remains unknown. We… Expand We have identified Xenopus homologs of the budding yeast Sld5 and its three interacting proteins. These form a novel complex… Expand Using a cytological assay to monitor the successive chromatin association of replication proteins leading to replication… Expand The initiation of eukaryotic DNA replication involves origin recruitment and activation of the MCM2-7 complex, the putative… Expand In eukaryotes, chromosomal DNA is licensed to be replicated through the sequential loading of the origin recognition complex… Expand The notochord has two major roles during chordate embryogenesis, as a source of inductive signals for the patterning of neural… Expand The initiation of DNA replication in Saccharomyces cerevisiae requires the protein product of the CDC45 gene. We report that… Expand