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CDC45L protein, human

Known as: Cell Division Cycle 45, S. cerevisiae, Homolog-Like, CDC45-Like, CDC45 Cell Division Cycle 45-Like (S. cerevisiae) 
CDC45-related protein (566 aa, ~66 kDa) is encoded by the human CDC45L gene. This protein is involved in the initiation of genomic DNA replication.
National Institutes of Health

Papers overview

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Review
2011
Review
2011
BackgroundIn eukaryotes, the CMG (CDC45, MCM, GINS) complex containing the replicative helicase MCM is a key player in DNA… Expand
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Highly Cited
2007
Highly Cited
2007
In eukaryotic cells, cyclin-dependent kinases (CDKs) have an important involvement at various points in the cell cycle. At the… Expand
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Highly Cited
2006
Highly Cited
2006
DNA damage induced by the carcinogen benzo[a]pyrene dihydrodiol epoxide (BPDE) induces a Chk1-dependent S-phase checkpoint. Here… Expand
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Highly Cited
2005
Highly Cited
2005
Cdc45 is required for initiation of DNA replication and fork progression, but its function in these processes remains unknown. We… Expand
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Highly Cited
2003
Highly Cited
2003
We have identified Xenopus homologs of the budding yeast Sld5 and its three interacting proteins. These form a novel complex… Expand
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Highly Cited
2003
Highly Cited
2003
Using a cytological assay to monitor the successive chromatin association of replication proteins leading to replication… Expand
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Highly Cited
2002
Highly Cited
2002
The initiation of eukaryotic DNA replication involves origin recruitment and activation of the MCM2-7 complex, the putative… Expand
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Highly Cited
2000
Highly Cited
2000
In eukaryotes, chromosomal DNA is licensed to be replicated through the sequential loading of the origin recognition complex… Expand
Highly Cited
2000
Highly Cited
2000
The notochord has two major roles during chordate embryogenesis, as a source of inductive signals for the patterning of neural… Expand
Highly Cited
1997
Highly Cited
1997
The initiation of DNA replication in Saccharomyces cerevisiae requires the protein product of the CDC45 gene. We report that… Expand