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Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells
TLDR
Clonal populations of human cervical epithelial cells which harbor multiple copies of either extrachromosomal or integrated viral DNA correlate with increased viral gene expression and cellular growth advantage, consistent with the hypothesis that integration provides a selective advantage to cervical epithelium precursors of cervical carcinoma.
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Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers.
TLDR
Findings in primary human tumors provide novel biomarkers for early detection of HPV(+) and HPV(-) cancers, and emphasize the potential value of targeting E6 and E7 function, alone or combined with radiation and/or traditional chemotherapy, in the treatment of HPV (+) cancers.
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Phosphorylation of p53 Serine 15 Increases Interaction with CBP*
TLDR
These results provide a mechanism for the activation of p53-regulated genes following DNA damage, through a signaling pathway linking p53 N-terminal kinase and C-Terminal acetyltransferase activities.
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A transcriptional repressor encoded by BPV-1 shares a common carboxy-terminal domain with the E2 transactivator
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Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis
TLDR
The use of the 10 key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis are described and a graphical representation of the identified mechanistic information is constructed.
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Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis.
  • S. Jeon, P. Lambert
  • Biology
    Proceedings of the National Academy of Sciences…
  • 28 February 1995
TLDR
It is demonstrated that integration of HPV-16 DNA leads to increased steady-state levels of mRNAs encoding the viral oncogenes E6 and E7, and that the A+U-rich element within this viral early 3' untranslated region confers instability on a heterologous mRNA.
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Merkel cell polyomavirus: a newly discovered human virus with oncogenic potential.
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Enhanced radiation sensitivity in HPV-positive head and neck cancer.
TLDR
These results provide clear evidence, and a supporting mechanism, for increased radiation sensitivity in HPV+ HNC relative to HPV- HNC, and suggest that low levels of normally functioning p53 in HPV+, which could be activated by radiation, leading to cell death.
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Evidence for a switch in the mode of human papillomavirus type 16 DNA replication during the viral life cycle
TLDR
Data argue that a fundamental switch in the mechanism of viral DNA replication occurs during the life cycle of the papillomavirus.
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Organization of Human Papillomavirus Productive Cycle during Neoplastic Progression Provides a Basis for Selection of Diagnostic Markers
TLDR
It appears from work that the presence of such proteins in cells at the epithelial surface allows the severity of the underlying disease to be predicted and that markers of viral gene expression may improve cervical screening.
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